Diagnostic value of serum squamous cell carcinoma antigen and cytokeratin fragment antigen 21-1 for sinonasal inverted papilloma: an exploratory study.

IF 4.8 2区医学 Q1 OTORHINOLARYNGOLOGY Rhinology Pub Date : 2024-06-01 DOI:10.4193/RhinRhin23.325

Z Zhang, B Xu, L Wang, X Yan, S Li, Y Jiang, L Yu

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Abstract

Background: Serum tumor markers have not yet been developed for the clinical diagnosis and treatment of sinonasal inverted papilloma (SNIP), one of the most significant sinonasal tumors. Therefore, this study aimed to determine the diagnostic value of serum squamous cell carcinoma antigen (SCCA) and cytokeratin fragment antigen 21-1 (CYFRA 21-1) for SNIP.

Methods: Clinical data were obtained from 101, 56, and 116 patients with SNIP, sinonasal squamous cell carcinoma (SNSCC), and unilateral chronic rhinosinusitis (CRS), respectively. Preoperative serum SCCA and CYFRA 21-1 levels were compared, and logistic regression analyses were performed to screen serum tumor markers, which may be used to diagnose SNIP. Diagnostic cut-off values were determined using receiver operating characteristic (ROC) curves, and their diagnostic power was verified.

Results: Serum SCCA and CYFRA 21-1 differentiated SNIP from CRS with the cut-off values of 1.97 ng/mL and 2.64 ng/mL and the areas under the ROC curves (AUC) of 0.895 and 0.766, respectively, and the AUC of the combination of the two markers was 0.909. CYFRA 21-1 differentiated SNIP with malignant transformation from that without malignant transformation with a cut-off value of 3.51 ng/mL and an AUC of 0.938. CYFRA 21-1 distinguished SNIP with malignant transformation from SNSCC with a cut-off value of 3.55 ng/mL and an AUC of 0.767.

Conclusions: This study provides novel potential diagnostic tools for SNIP by demonstrating the use of serum SCCA and CYFRA 21-1 in the diagnosis of SNIP.

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血清鳞状细胞癌抗原和细胞角蛋白片段抗原 21-1 对鼻窦倒置乳头状瘤的诊断价值：一项探索性研究。

背景：鼻窦倒置乳头状瘤（SNIP）是最重要的鼻窦肿瘤之一，目前尚未开发出用于鼻窦倒置乳头状瘤临床诊断和治疗的血清肿瘤标志物。因此，本研究旨在确定血清鳞状细胞癌抗原（SCCA）和细胞角蛋白片段抗原 21-1（CYFRA 21-1）对鼻窦倒置乳头状瘤的诊断价值：分别从101例、56例和116例SNIP、鼻窦鳞状细胞癌（SNSCC）和单侧慢性鼻窦炎（CRS）患者中获取临床数据。对术前血清 SCCA 和 CYFRA 21-1 水平进行了比较，并进行了逻辑回归分析，以筛选可用于诊断 SNIP 的血清肿瘤标志物。利用接收器操作特征曲线（ROC）确定诊断临界值，并验证其诊断能力：结果：血清SCCA和CYFRA 21-1可将SNIP与CRS区分开来，其临界值分别为1.97纳克/毫升和2.64纳克/毫升，ROC曲线下面积（AUC）分别为0.895和0.766，两种标记物组合的AUC为0.909。CYFRA 21-1 能区分有恶性转化和无恶性转化的 SNIP，其临界值为 3.51 ng/mL，AUC 为 0.938。CYFRA 21-1 能将有恶性转化的 SNIP 与 SNSCC 区分开来，其临界值为 3.55 纳克/毫升，AUC 为 0.767：本研究通过证明血清 SCCA 和 CYFRA 21-1 在诊断 SNIP 中的应用，为 SNIP 提供了新的潜在诊断工具。

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来源期刊

Rhinology 医学-耳鼻喉科学

CiteScore

15.80

自引率

9.70%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Rhinology serves as the official Journal of the International Rhinologic Society and is recognized as one of the journals of the European Rhinologic Society. It offers a prominent platform for disseminating rhinologic research, reviews, position papers, task force reports, and guidelines to an international scientific audience. The journal also boasts the prestigious European Position Paper in Rhinosinusitis (EPOS), a highly influential publication first released in 2005 and subsequently updated in 2007, 2012, and most recently in 2020. Employing a double-blind peer review system, Rhinology welcomes original articles, review articles, and letters to the editor.