Longitudinal associations between gut microbiome diversity and emotional well-being.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-01 Epub Date: 2024-01-08 DOI:10.1037/hea0001350

Sung-Ha Lee, Xyle Ku, Hyun-Seok Oh, Yeonjae Jung, Jongsik Chun, Incheol Choi

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Abstract

Objective: While a significant link between emotional well-being (EWB) and the gut microbiome has been reported recently, their temporal relationships remain elusive. This study aims to fill this gap by examining the longitudinal associations between EWB and the Shannon Index (SI), an indicator of gut microbiome diversity.

Method: The analysis focused on a dataset that collected participants' current EWB and fecal samples in both 2019 and 2022 (N = 57, 56.1% female, M_age = 52.47 years, SD = 12.65). Gut microbiome profiles were generated by sequencing the 16S rRNA gene, from which SI was subsequently calculated.

Results: The cross-lagged panel analysis revealed significant positive cross-sectional associations between EWB and SI in both 2019 (β = .296, SE = 0.121, p = .014) and 2022 (β = .324, SE = 0.119, p = .006). However, no significant longitudinal associations were found between 2019 EWB and 2022 SI (β = .068, SE = 0.138, p = .623), nor between 2019 SI and 2022 EWB (β = -.016, SE = 0.13, p = .899).

Conclusions: Our findings indicate that emotional happiness may be associated with gut microbiome profiles at a particular time point, but they may not serve as predictive factors for each other over time. Future research is needed to establish causal relationships between them. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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肠道微生物组多样性与情绪健康之间的纵向联系。

目的：尽管最近有报道称情绪幸福感（EWB）与肠道微生物组之间存在重要联系，但它们之间的时间关系仍然难以捉摸。本研究旨在通过研究情绪幸福感与香农指数（SI）（肠道微生物组多样性的指标）之间的纵向关系来填补这一空白：分析的重点是收集参与者在 2019 年和 2022 年的当前 EWB 和粪便样本的数据集（N = 57，56.1% 为女性，年龄 = 52.47 岁，SD = 12.65）。通过 16S rRNA 基因测序生成了肠道微生物组图谱，随后计算出 SI：交叉滞后面板分析显示，2019 年（β = .296，SE = 0.121，p = .014）和 2022 年（β = .324，SE = 0.119，p = .006）EWB 与 SI 之间均存在显著的正向横断面关联。然而，在 2019 年 EWB 和 2022 年 SI 之间（β = .068，SE = 0.138，p = .623），以及 2019 年 SI 和 2022 年 EWB 之间（β = -.016，SE = 0.13，p = .899），均未发现明显的纵向关联：我们的研究结果表明，在特定的时间点，情绪幸福感可能与肠道微生物组特征相关，但随着时间的推移，它们可能并不是彼此的预测因素。未来的研究需要确定它们之间的因果关系。(PsycInfo Database Record (c) 2024 APA, 版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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