Predictive Value of Fractional Exhaled Nitric Oxide (FeNO) in the Diagnosis of Asthma for Epidemiological Purposes—An 8-Year Follow-Up Study

IF 1.8 Q3 RESPIRATORY SYSTEM Advances in respiratory medicine Pub Date : 2024-01-04 DOI:10.3390/arm92010006
K. Barański
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Abstract

At the population level, respiratory symptoms in children can be estimated cross-sectionally. However, such methods require additional objective support parameters, such as the measurement of fractional exhaled nitric oxide (FeNO). The aim of the present study was to analyze if the FeNO value measured at baseline can have a predictive value for asthma-like symptoms after 8 years of measurement. Methods: The follow-up included 128 (out of 447) children, 70 girls and 58 boys. The FeNO was measured at baseline only. The prevalence of asthma-like symptoms was measured with the adopted version of the ISAAC questionnaire. Results: After 8 years of FeNO measurement, 5 new cases of asthma, 2 cases of attacks of dyspnoea, 1 case of wheezy in the chest, and 18 cases of allergic rhinitis occurred. The FeNO values, measured at the baseline of the study, for new cases of the above diseases were 53.4 ± 75.9 ppb, 11 ± 1.5 ppb, 12.0 ppb, and 16.3 ± 12.4 ppb, respectively. The best diagnostic accuracy parameters were found in the new cases of asthma, where the sensitivity was 40.0%, the specificity was 98.6%, and the AUC was 66.6%. The diagnostic odds ratio was 46.9 when considering the FeNO cut-off >35 ppb. Conclusions: The FeNO measurement is a fair method for asthma prognosis in early school-aged children with asthma-like symptoms measured on the population level but requires further confirmation at the clinical level with more accurate diagnostic tools.
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分量呼出一氧化氮(FeNO)在哮喘诊断中的流行病学预测价值--一项为期 8 年的随访研究
在人口层面,儿童的呼吸道症状可以通过横截面进行估算。然而,这种方法需要额外的客观支持参数,如测量呼出一氧化氮分数(FeNO)。本研究旨在分析基线时测量的一氧化氮值是否对 8 年后的哮喘样症状具有预测价值。研究方法随访对象包括 128 名儿童(共 447 名),其中 70 名女孩,58 名男孩。仅在基线时测量 FeNO 值。哮喘样症状的发生率通过采用的 ISAAC 问卷进行测量。结果显示经过 8 年的 FeNO 测量,新出现了 5 例哮喘、2 例呼吸困难发作、1 例胸部喘息和 18 例过敏性鼻炎。上述疾病新病例在研究基线测量的 FeNO 值分别为 53.4 ± 75.9 ppb、11 ± 1.5 ppb、12.0 ppb 和 16.3 ± 12.4 ppb。哮喘新病例的诊断准确性参数最佳,灵敏度为 40.0%,特异度为 98.6%,AUC 为 66.6%。当 FeNO 临界值大于 35 ppb 时,诊断几率比为 46.9。结论在人群水平上测量 FeNO 是对有类似哮喘症状的学龄前儿童进行哮喘预后判断的一种公平方法,但在临床水平上还需要更精确的诊断工具来进一步确认。
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来源期刊
Advances in respiratory medicine
Advances in respiratory medicine RESPIRATORY SYSTEM-
CiteScore
2.60
自引率
0.00%
发文量
90
期刊介绍: "Advances in Respiratory Medicine" is a new international title for "Pneumonologia i Alergologia Polska", edited bimonthly and addressed to respiratory professionals. The Journal contains peer-reviewed original research papers, short communications, case-reports, recommendations of the Polish Respiratory Society concerning the diagnosis and treatment of lung diseases, editorials, postgraduate education articles, letters and book reviews in the field of pneumonology, allergology, oncology, immunology and infectious diseases. "Advances in Respiratory Medicine" is an open access, official journal of Polish Society of Lung Diseases, Polish Society of Allergology and National Research Institute of Tuberculosis and Lung Diseases.
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