A multicenter study of cervical cancer using quantitative diffusion-weighted imaging.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-07-01 Epub Date: 2024-01-09 DOI:10.1177/02841851231222360
Xue Wang, Zhijun Ye, Shujian Li, Zhihan Yan, Jingliang Cheng, Gang Ning, Zujun Hou
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Abstract

Background: Parameters from diffusion-weighted imaging (DWI) have been increasingly used as imaging biomarkers for the diagnosis and monitoring of treatment responses in cancer. The consistency of DWI measurements across different centers remains uncertain, which limits the widespread use of quantitative DWI in clinical settings.

Purpose: To investigate the consistency of quantitative metrics derived from DWI between different scanners in a multicenter clinical setting.

Material and methods: A total of 193 patients with cervical cancer from four scanners (MRI1, MRI2, MRI3, and MRI4) at three centers were included in this retrospective study. DWI data were processed using the mono-exponential and intravoxel incoherent motion (IVIM) model, yielding the following parameters: apparent diffusion coefficient (ADC); true diffusion coefficient (D); pseudo-diffusion coefficient (D*); perfusion fraction (f); and the product of f and D* (fD*). Various parameters of cervical cancer obtained from different scanners were compared.

Results: The parameters D and ADC derived from MRI1 and MRI2 were significantly different from those derived from MRI3 or MRI4 (P <0.01 for all comparisons). However, there was no significant difference in cervical cancer perfusion parameters (D* and fD*) between the different scanners (P >0.05). The P values of comparisons of all DWI parameters (D, D*, fD*, and ADC) between MRI3 and MRI4 (same vendor in different centers) for cervical cancer were all >0.05, except for f (P = 0.05).

Conclusion: Scanners of the same model by the same vendor can yield close measurements of the ADC and IVIM parameters. The perfusion parameters showed higher consistency among the different scanners.

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利用定量弥散加权成像对宫颈癌进行多中心研究。
背景:弥散加权成像(DWI)参数已越来越多地被用作诊断和监测癌症治疗反应的成像生物标志物。不同中心的 DWI 测量结果的一致性仍不确定,这限制了定量 DWI 在临床环境中的广泛应用。目的:在多中心临床环境中研究不同扫描仪的 DWI 定量指标的一致性:这项回顾性研究共纳入了三个中心四台扫描仪(MRI1、MRI2、MRI3 和 MRI4)的 193 名宫颈癌患者。采用单指数和体素内不连贯运动(IVIM)模型处理 DWI 数据,得出以下参数:表观扩散系数(ADC);真实扩散系数(D);假扩散系数(D*);灌注分数(f);以及 f 与 D* 的乘积(fD*)。对不同扫描仪获得的宫颈癌各种参数进行了比较:结果:核磁共振成像 1 和核磁共振成像 2 得出的 D 和 ADC 参数与核磁共振成像 3 或核磁共振成像 4 得出的参数有显著差异(P P >0.05)。宫颈癌 MRI3 和 MRI4(不同中心的同一供应商)的所有 DWI 参数(D、D*、fD* 和 ADC)比较的 P 值均大于 0.05,但 f 除外(P = 0.05):结论:同一供应商生产的同型号扫描仪可以测量出接近的 ADC 和 IVIM 参数。不同扫描仪的灌注参数一致性更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta radiologica
Acta radiologica 医学-核医学
CiteScore
2.70
自引率
0.00%
发文量
170
审稿时长
3-8 weeks
期刊介绍: Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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