Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases.

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-06-01 Epub Date: 2024-01-09 DOI:10.1007/s10585-023-10253-3
Yoshiya Horimoto, May Thinzar Hlaing, Harumi Saeki, Kaori Denda-Nagai, Katrin Ishii-Schrade, Haruhiko Fujihira, Masaaki Abe, Miki Noji, Shigeyuki Shichino, Mitsue Saito, Tatsuro Irimura
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Abstract

Glycosylation changes of cancer cells are known to be associated with malignant progression and metastases and potentially determine the organ-selective nature of metastasis as theorized by Paget (Lancet 1:571-573, 1889). Cellular glycans play a variety of roles in the processes of metastasis and may be unique to the cells that metastasize to different organs. We analyzed the glycosylation profiles of the primary tumor and tumors metastasized to lymph node, liver, lung, brain, bone, thyroid, kidney, adrenal, small intestine and pancreas in an autopsy case of breast cancer employing a lectin microarray with 45 lectins. Clustering analysis of the data revealed that metastatic breast cancer cells were categorized into several clusters according to their glycosylation profiles. Our results provide a biological basis to understand differential phenotypes of metastatic breast cancer cells potentially reflecting clonal origin, which does not directly reflect genomic or genetic changes or microenvironmental effects but connects to glycosylation profiles.

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乳腺癌细胞的糖基化特征可能代表多器官转移的克隆变异。
众所周知,癌细胞的糖基化变化与恶性进展和转移有关,并有可能决定转移的器官选择性,正如 Paget(《柳叶刀》1:571-573,1889 年)所推测的那样。细胞聚糖在转移过程中起着多种作用,可能是转移到不同器官的细胞所特有的。我们利用含有 45 种凝集素的凝集素芯片分析了乳腺癌尸检病例中原发肿瘤和转移到淋巴结、肝、肺、脑、骨、甲状腺、肾、肾上腺、小肠和胰腺的肿瘤的糖基化特征。对数据的聚类分析显示,转移性乳腺癌细胞根据其糖基化特征被分为几个群组。我们的研究结果为了解转移性乳腺癌细胞的不同表型提供了生物学基础,这些表型可能反映了克隆起源,但并不直接反映基因组或遗传变化或微环境影响,而是与糖基化图谱有关。
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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