Exacerbated prognostic impact of multiple intramural metastasis versus single intramural metastasis of thoracic esophageal squamous cell carcinoma: evidence from an Uzbekistan cohort.
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引用次数: 0
Abstract
Purpose: Intramural metastasis (IM) is a poor prognostic factor for patients with esophageal squamous cell carcinoma (ESCC). We conducted this study to assess the prognostic impact of IM in an Uzbekistan cohort and to identify the factors associated with the poor prognosis of patients with ESCC and IM.
Methods: The subjects of this retrospective analysis were 1083 patients with thoracic ESCC, who underwent curative esophagectomy between 2001 and 2021 at the National Cancer Center of Uzbekistan. We compared the clinicopathological characteristics and survival outcomes of patients with versus those without IM and evaluated the factors associated with the poor prognosis of patients with IM.
Results: Patients with pathological IM (n = 59, 5.4%) were significantly older, had a higher percentage of lymphatic invasion and worse pathological N stage, and had shorter overall survival (OS) than patients without IM. Multivariable analysis of OS identified multiple IMs as the only independent prognostic factor in patients with IM (hazard ratio, 6.04; 95% confidence interval, 2.77-13.18; P < 0.001). Patients with multiple IMs had shorter OS and recurrence-free survival than those with a single IM.
Conclusion: IM was a poor prognostic factor for patients with ESCC in this Uzbekistan cohort and multiple IMs were associated with worse outcomes.
目的:壁内转移(IM)是食管鳞状细胞癌(ESCC)患者预后不良的一个因素。我们进行了这项研究,以评估乌兹别克斯坦队列中 IM 对预后的影响,并确定与 ESCC 和 IM 患者预后不良相关的因素:这项回顾性分析的对象是2001年至2021年间在乌兹别克斯坦国立癌症中心接受根治性食管切除术的1083名胸部ESCC患者。我们比较了有IM和无IM患者的临床病理特征和生存结果,并评估了与IM患者预后不良相关的因素:病理 IM 患者(59 人,占 5.4%)与无 IM 患者相比,年龄明显偏大,淋巴浸润比例较高,病理 N 分期较差,总生存期(OS)较短。OS的多变量分析发现,多个IM是IM患者唯一的独立预后因素(危险比,6.04;95%置信区间,2.77-13.18;P 结论:IM是IM患者的不良预后因素:在乌兹别克斯坦队列中,IM是ESCC患者的不良预后因素,多个IM与较差的预后相关。
期刊介绍:
Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it").
The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.