The Bone-Vascular Axis in Chronic Kidney Disease: From Pathophysiology to Treatment.

IF 4.3 2区医学 Current Osteoporosis Reports Pub Date : 2024-02-01 Epub Date: 2024-01-10 DOI:10.1007/s11914-023-00858-8

Clément Vachey, Alexandre Candellier, Soline Toutain, Fabrice Mac-Way

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Abstract

Purpose of review: This review aims to describe the pathogenic factors involved in bone-vessel anomalies in CKD which are the object of numerous experimental and clinical research.

Recent findings: Knowledge on the pathophysiological mechanisms involved in the regulation of vascular calcification and mineral-bone disorders is evolving. Specific bone turnover anomalies influence the vascular health while recent studies demonstrate that factors released by the calcified vessels also contribute to bone deterioration in CKD. Current therapies used to control mineral dysregulations will impact both the vessels and bone metabolism. Available anti-osteoporotic treatments used in non-CKD population may negatively or positively affect vascular health in the context of CKD. It is essential to study the bone effects of the new therapeutic options that are currently under investigation to reduce vascular calcification. Our paper highlights the complexity of the bone-vascular axis and discusses how current therapies may affect both organs in CKD.

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慢性肾病的骨血管轴：从病理生理学到治疗。

综述的目的：本综述旨在描述慢性肾脏病骨血管异常的致病因素，这些因素是众多实验和临床研究的对象：最近的研究结果：关于血管钙化和矿物质-骨骼紊乱的病理生理机制的知识正在不断发展。特定的骨转换异常会影响血管健康，而最近的研究表明，钙化血管释放的因子也会导致慢性肾脏病患者的骨质恶化。目前用于控制矿物质失调的疗法会同时影响血管和骨代谢。用于非慢性肾脏病人群的现有抗骨质疏松治疗可能会对慢性肾脏病患者的血管健康产生负面或正面影响。研究目前正在研究的减少血管钙化的新疗法对骨骼的影响至关重要。我们的论文强调了骨-血管轴的复杂性，并讨论了目前的疗法会如何影响慢性肾脏病患者的这两个器官。

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Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

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期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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