The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-04-01 Epub Date: 2024-01-11 DOI:10.1007/s11154-023-09865-7
Rosalind Walmsley, Lynn Chong, Michael W Hii, Robyn M Brown, Priya Sumithran
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Abstract

Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of bariatric surgery. Databases searched included Medline, Embase, Emcare, APA PsychInfo, Cochrane Library, and CINAHL. Two human and 21 animal studies were included. Bariatric surgery alters the quantity of many sweet, umami, and fatty acid taste receptors in the gastrointestinal tract. Changes to the expression of sweet and amino acid receptors occur most often in intestinal segments surgically repositioned more proximally, such as the alimentary limb after gastric bypass. Conversely, changes to fatty acid receptors were observed more frequently in the colon than in the small intestine. Significant heterogeneity in the methodology of included studies limited conclusions regarding the direction of change in taste receptor expression induced by bariatric surgeries. Few studies have investigated associations between taste receptor expression and clinical outcomes of bariatric surgery. As such, future studies should look to investigate the relationship between bariatric surgery-induced changes to gut taste receptor expression and function and the impact of surgery on taste preferences, food palatability, and eating behaviour.Registration code in PROSPERO: CRD42022313992.

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减肥手术对胃肠味觉受体表达的影响:系统综述。
通过味觉受体感知胃肠道营养可能有助于减肥、改善新陈代谢以及减少减肥手术后对甜食和油腻食物的偏好。本综述旨在研究减肥手术对口腔和口腔后胃肠道味觉受体表达的影响,以及味觉受体改变与减肥手术临床效果之间的关联。我们进行了一项系统性综述,从人类和动物研究中获取了有关任何类型减肥手术后口腔或口后胃肠道组织中味觉受体表达变化的数据。检索的数据库包括 Medline、Embase、Emcare、APA PsychInfo、Cochrane Library 和 CINAHL。其中包括两项人类研究和 21 项动物研究。减肥手术改变了胃肠道中许多甜味、鲜味和脂肪酸味觉受体的数量。甜味受体和氨基酸受体表达的改变最常发生在手术复位较近的肠段,如胃旁路术后的消化肢。相反,在结肠中观察到脂肪酸受体变化的频率高于小肠。纳入研究的方法存在显著的异质性,这限制了就减肥手术引起的味觉受体表达变化方向得出结论。很少有研究调查了味觉受体表达与减肥手术临床结果之间的关系。因此,未来的研究应着眼于调查减肥手术引起的肠道味觉受体表达和功能变化与手术对味觉偏好、食物适口性和饮食行为的影响之间的关系。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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