Correction: A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

Abstract

Correction: Translational Neurodegeneration 12:51 (2023) https://doi.org/10.1186/s40035-023-00379-5

Following publication of the original article [1], the authors reported an error in the Fig. 2:

Figure 2e presented a typing error "HT7" was wrongly written as "HT1". See the Fig. 2 corrected

Fig. 2

Increase of phosphorylated tau in the hippocampus of dox-administered hTau368 mice. a Diagram of human tau protein structure and phosphorylation epitopes measured in this study. b, c Dox treatment for 2 months showed no infuence on tau expression and phosphorylation in wild-type mice. Unpaired Student’s t-test, P > 0.05, n = 3 mice in each group. d, e Dox-treated hTau368 mice had higher levels of phosphorylated tau in the RIPA-soluble lysate of hippocampus. Homozygotes showed much more prominent pTau increase than hemizygotes. One-way ANOVA followed by Tukey’s multiple comparisons tests, *P < 0.05, **P < 0.01, ***P < 0.001, compared with the Veh group (n = 4 mice); ^#P < 0.05, Dox-Homo (n = 3 mice) compared with the Dox-Hemi group (n = 3 mice). f–h pTau aggregation in the hippocampus of Dox-treated hTau368 mice, detected by immunostaining for pS181, pS199 and AT8 tau. One-way ANOVA followed by Tukey’s multiple comparisons tests, ***P < 0.001, n = 3 mice in each group. i, j Dox-treated homozygous hTau368 mice had high levels of pTau in the RIPA-insoluble lysate of hippocampus. One-way ANOVA followed by Tukey’s multiple comparisons tests, *P < 0.05, compared with the Veh group, n = 3–4 mice in each group

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The original article [1] has been corrected.

1. Gao Y, Wang Y, Lei H, et al. A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau. Transl Neurodegener. 2023;12:51. https://doi.org/10.1186/s40035-023-00379-5.

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Authors and Affiliations

1. Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

   Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Gongping Liu & Jian‑Zhi Wang

2. Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430030, China

   Zhentao Zhang

3. Key Laboratory of Ministry of Education for Neurological Disorders, Department of Endocrine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, China

   Yao Zhang

4. Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University , Beijing, China

   Jie Zheng

5. Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, 100083, China

   Jie Zheng

6. Co‑Innovation Center of Neuroregeneration, Nantong University, Nantong, 226000, China

   Jian‑Zhi Wang

Authors

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2. Yuying WangView author publications

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3. Huiyang LeiView author publications

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4. Zhendong XuView author publications

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6. Haitao YuView author publications

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8. Zhentao ZhangView author publications

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9. Gongping LiuView author publications

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10. Yao ZhangView author publications

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11. Jie ZhengView author publications

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12. Jian‑Zhi WangView author publications

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Corresponding authors

Correspondence to Yang Gao, Yao Zhang, Jie Zheng or Jian‑Zhi Wang.

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Gao, Y., Wang, Y., Lei, H. et al. Correction: A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau. Transl Neurodegener 13, 5 (2024). https://doi.org/10.1186/s40035-024-00396-y

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• Published: 11 January 2024

• DOI: https://doi.org/10.1186/s40035-024-00396-y

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