Cellular models in autoinflammatory disease research

IF 4.6 2区 医学 Q2 IMMUNOLOGY Clinical & Translational Immunology Pub Date : 2024-01-11 DOI:10.1002/cti2.1481
Başak Şen, Banu Balcı-Peynircioğlu
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Abstract

Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders caused by dysregulation of the innate immune system. Understanding the complex mechanisms underlying these conditions is critical for developing effective treatments. Cellular models are essential for identifying new conditions and studying their pathogenesis. Traditionally, these studies have used primary cells and cell lines of disease-relevant cell types, although newer induced pluripotent stem cell (iPSC)-based models might have unique advantages. In this review, we discuss the three cellular models used in autoinflammatory disease research, their strengths and weaknesses, and their applications to inform future research in the field.

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自身炎症性疾病研究中的细胞模型
全身性自身炎症性疾病是一类由先天性免疫系统失调引起的罕见遗传性疾病。了解这些疾病的复杂机制对于开发有效的治疗方法至关重要。细胞模型对于确定新病症和研究其发病机制至关重要。尽管基于诱导多能干细胞(iPSC)的新型模型可能具有独特的优势,但传统上,这些研究一直使用原代细胞和疾病相关细胞类型的细胞系。在这篇综述中,我们将讨论自身炎症性疾病研究中使用的三种细胞模型、它们的优缺点及其应用,为该领域未来的研究提供参考。
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来源期刊
Clinical & Translational Immunology
Clinical & Translational Immunology Medicine-Immunology and Allergy
CiteScore
12.00
自引率
1.70%
发文量
77
审稿时长
13 weeks
期刊介绍: Clinical & Translational Immunology is an open access, fully peer-reviewed journal devoted to publishing cutting-edge advances in biomedical research for scientists and physicians. The Journal covers fields including cancer biology, cardiovascular research, gene therapy, immunology, vaccine development and disease pathogenesis and therapy at the earliest phases of investigation.
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