On the edge: how nuclear pore complexes rule genome stability

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-01-12 DOI:10.1016/j.gde.2023.102150
Marie-Noëlle Simon , Karine Dubrana , Benoit Palancade
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Abstract

Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity of nuclear pore complexes (NPCs), where specific repair pathways are favored, ultimately safeguarding genome integrity. Here, we review the most recent progress in this field, notably highlighting the increasingly diverse types of DNA structures undergoing repositioning, and the signaling pathways involved. We further discuss our growing knowledge of the molecular mechanisms underlying the choice of repair pathways at NPCs, and their conservation — or divergences. Intriguingly, a series of recent findings suggest that DNA metabolism may be coupled to NPC biogenesis and specialization, challenging our initial vision of these processes.

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边缘:核孔复合体如何决定基因组的稳定性。
核组织已成为协调 DNA 修复活动的关键层。研究表明,不同类型的 DNA 病变会迁移到核孔复合体(NPC)附近,而特定的修复途径会在这些地方受到青睐,最终保护基因组的完整性。在此,我们回顾了这一领域的最新进展,特别强调了发生重新定位的 DNA 结构日益多样化的类型,以及所涉及的信号通路。我们还进一步讨论了我们对 NPC 修复途径选择的分子机制及其保护或分歧的日益增长的知识。耐人寻味的是,最近的一系列发现表明,DNA 新陈代谢可能与 NPC 的生物发生和特化相关联,这对我们最初对这些过程的看法提出了挑战。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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