Late-spiking retrosplenial cortical neurons are not synchronized with neocortical slow waves in anesthetized mice

IF 2.4 4区 医学 Q3 NEUROSCIENCES Neuroscience Research Pub Date : 2024-01-14 DOI:10.1016/j.neures.2024.01.001
Hiroyuki Mizuno , Yuji Ikegaya
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Abstract

Neocortical slow waves are critical for memory consolidation. The retrosplenial cortex is thought to facilitate the slow wave propagation to regions beyond the neocortex. However, it remains unclear which population is responsible for the slow wave propagation. To address this issue, we performed in vivo whole-cell recordings to identify neurons that were synchronous and asynchronous with slow waves. By quantifying their intrinsic membrane properties, we observed that the former exhibited regular spiking, whereas the latter exhibited late spiking. Thus, these two cell types transmit information in different directions between the neocortex and subcortical regions.

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麻醉小鼠的晚期尖峰后叶皮层神经元与新皮层慢波不同步
新皮质慢波对记忆巩固至关重要。后脾皮层被认为能促进慢波向新皮层以外的区域传播。然而,目前仍不清楚哪个群体负责慢波传播。为了解决这个问题,我们进行了体内全细胞记录,以确定与慢波同步和不同步的神经元。通过量化它们的内在膜特性,我们观察到前者表现出有规律的尖峰脉冲,而后者则表现出晚期尖峰脉冲。因此,这两种细胞在新皮层和皮层下区域之间以不同的方向传递信息。
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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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