Alexander M. Ille, Christopher Markosian, Stephen K. Burley, Michael B. Mathews, R. Pasqualini, W. Arap
{"title":"Generative artificial intelligence performs rudimentary structural biology modelling","authors":"Alexander M. Ille, Christopher Markosian, Stephen K. Burley, Michael B. Mathews, R. Pasqualini, W. Arap","doi":"10.1101/2024.01.10.575113","DOIUrl":null,"url":null,"abstract":"Generative artificial intelligence (AI) is being increasingly used by researchers in numerous fields of study, including the biological sciences. To date, the most commonly used tool grounded in this technology has been Chat Generative Pre-trained Transformer (ChatGPT). While ChatGPT is typically applied for natural language text generation, other application modes include coding and mathematical problem-solving. We have recently reported the ability of ChatGPT to interpret the central dogma of molecular biology and the genetic code. Here we explored how ChatGPT performs rudimentary structural biology modelling in order to gain evaluative insight. We prompted ChatGPT to model 3D structures for the 20 standard amino acids as well as an α-helical polypeptide chain, with the latter involving incorporation of the Wolfram plugin for advanced mathematical computation. For amino acid modelling, distances and angles between atoms of the generated structures in most cases approximated to around experimentally-determined values. For α-helix modelling, the generated structures were comparable to that of an experimentally-determined α-helical structure. However, both amino acid and α-helix modelling were sporadically error-prone and increased molecular complexity was not well tolerated. Despite current limitations, our findings show the capability of generative AI to perform basic structural biology modelling with atomic-scale accuracy. These results provide a precedent for the potential use of generative AI in structural biology as this technology continues to advance.","PeriodicalId":505198,"journal":{"name":"bioRxiv","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.01.10.575113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Generative artificial intelligence (AI) is being increasingly used by researchers in numerous fields of study, including the biological sciences. To date, the most commonly used tool grounded in this technology has been Chat Generative Pre-trained Transformer (ChatGPT). While ChatGPT is typically applied for natural language text generation, other application modes include coding and mathematical problem-solving. We have recently reported the ability of ChatGPT to interpret the central dogma of molecular biology and the genetic code. Here we explored how ChatGPT performs rudimentary structural biology modelling in order to gain evaluative insight. We prompted ChatGPT to model 3D structures for the 20 standard amino acids as well as an α-helical polypeptide chain, with the latter involving incorporation of the Wolfram plugin for advanced mathematical computation. For amino acid modelling, distances and angles between atoms of the generated structures in most cases approximated to around experimentally-determined values. For α-helix modelling, the generated structures were comparable to that of an experimentally-determined α-helical structure. However, both amino acid and α-helix modelling were sporadically error-prone and increased molecular complexity was not well tolerated. Despite current limitations, our findings show the capability of generative AI to perform basic structural biology modelling with atomic-scale accuracy. These results provide a precedent for the potential use of generative AI in structural biology as this technology continues to advance.