{"title":"CAR-T Cell Therapy: Advances in Kidney-Related Diseases","authors":"Longyuan Wu, Youqin Feng, Yue Huang, Jingjing Feng, Yong-xian Hu, He Huang","doi":"10.1159/000536194","DOIUrl":null,"url":null,"abstract":"Currently, renal malignancies and some diseases accompanied by renal impairment, such as multiple myeloma (MM), systemic lupus erythematosus (SLE), and acquired immunodeficiency syndrome (AIDS) are characterized by encouraging benefits from immunotherapy that have led to significantly improved outcomes. In this regard, the chimeric antigen receptor (CAR)-T represents a further step forward in the field of immunotherapy, which is becoming a hot issue and revealing potential in these diseases. Additionally, with numerous novel targets and indications being discovered and tried for clinical practice, the nephrotoxicity associated with CAR-T cell therapy also needs attention. In this review, we focused on discussing the effects and drawbacks of CAR-T cell therapy in several common diseases involving kidneys, as well as how we might enhance it.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000536194","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
Abstract
Currently, renal malignancies and some diseases accompanied by renal impairment, such as multiple myeloma (MM), systemic lupus erythematosus (SLE), and acquired immunodeficiency syndrome (AIDS) are characterized by encouraging benefits from immunotherapy that have led to significantly improved outcomes. In this regard, the chimeric antigen receptor (CAR)-T represents a further step forward in the field of immunotherapy, which is becoming a hot issue and revealing potential in these diseases. Additionally, with numerous novel targets and indications being discovered and tried for clinical practice, the nephrotoxicity associated with CAR-T cell therapy also needs attention. In this review, we focused on discussing the effects and drawbacks of CAR-T cell therapy in several common diseases involving kidneys, as well as how we might enhance it.
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