To explore the pathogenesis and scientific connotation of non-alcoholic fatty liver based on the theory of turbid toxin of traditional Chinese medicine

Guanjun Kou, Hongwei Luo, Xing Huang, Mingxue Bai, Ke Cao, Hongyu Ma, Xiang Lv
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is a metabolic liver disease characterized by the accumulation of excessive liver lipids without alcohol-induced damage. It has emerged as a significant global health issue. A recent research has indicated that dysregulation of lipid decomposition, uptake, production, oxidation, and secretion causes alterations in various types of lipids, leading to organelle dysfunction and metabolic signaling pathway impairment. Scholars propose that turbid toxin is crucial in the pathogenesis of NAFLD. This article elucidates the meaning of turbid toxin in conjunction with the current literature and analyzes the modern pathophysiological mechanism underlying the development of NAFLD, including turbid toxic substance production, related organelle involvement, biological processes, and pathways, ultimately leading to disease outcomes. The relationship between traditional Chinese medicine and the turbid toxin is also explored to establish a foundation for further mechanistic research on NAFLD.

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以中医浊毒理论为基础,探讨非酒精性脂肪肝的发病机理及科学内涵
非酒精性脂肪肝(NAFLD)是一种代谢性肝病,其特点是肝脏脂质过多堆积,但没有酒精引起的损伤。它已成为一个重要的全球健康问题。最近的一项研究表明,脂质分解、摄取、生成、氧化和分泌失调会引起各类脂质的改变,从而导致细胞器功能障碍和代谢信号通路受损。有学者提出,浊毒素在非酒精性脂肪肝的发病机制中起着关键作用。本文结合现有文献阐明了浊毒的含义,并分析了非酒精性脂肪肝发病的现代病理生理机制,包括浊毒物质的产生、相关细胞器的参与、生物学过程和途径,最终导致疾病的结局。此外,还探讨了中药与浊毒的关系,为进一步开展非酒精性脂肪肝的机理研究奠定基础。
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