B-Zell-mediierte Autoimmunerkrankungen: Risiko für B-Zell-Lymphome?

Abstract

Primary cutaneous B-cell lymphomas (pcBCLs) are non-Hodgkin lymphomas present in the skin without evidence of extracutaneous involvement at diagnosis and include primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, intravascular large B-cell lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg-type [1]. While the etiology and pathogenesis of pcBCL is not fully understood, prior research suggests a possible association between autoimmune disease and primary cutaneous marginal zone lymphoma [2]. While it is known that patients with certain autoimmune disorders (systemic lupus erythematosus, autoimmune thyroiditis, Sjogren‘s, and sarcoidosis, among others) have an increased risk of developing non-Hodgkin lymphomas and other cancers due to chronic B-cell stimulation and immune dysregulation, little is known about the relationship between specific autoimmune diseases and pcBCL [3, 4].