Asociación del colesterol remanente con el grado de control glucémico y la presencia de complicaciones microvasculares en personas con diabetes mellitus tipo 1

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Revista clinica espanola Pub Date : 2024-01-01 DOI:10.1016/j.rce.2023.11.002

J.J. Raposo-López, M.S. Tapia-Sanchiz, V. Navas-Moreno, J.A. Arranz Martín, M. Marazuela, F. Sebastián-Valles

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Abstract

Introduction

This study examines the relationship between remnant cholesterol, glucose metrics, and chronic complications of type 1 diabetes in users of glucose monitoring systems.

Material and methods

Clinical variables and glucose metrics were collected from individuals using glucose sensors. Statistical models were employed to investigate the association of remnant cholesterol with glucose metrics, diabetic retinopathy, and diabetic nephropathy.

Results

A total of 383 individuals, aged 48.3 ± 16.2 years, with 54.1% women, and a remnant cholesterol level of 16 ± 10 mg/dL, were included. The results demonstrated that remnant cholesterol was associated with less time within the target range (P=.015) and more time above the target range (P=.003). Diabetic nephropathy was the only complication associated with remnant cholesterol levels exceeding 30 mg/dL; OR: 8.93; 95% CI: 2.99-26.62, P<.001.

Conclusion

Remnant cholesterol is independently associated with hyperglycemia and diabetic nephropathy in individuals with type 1 diabetes.

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剩余胆固醇与 1 型糖尿病患者血糖控制程度和微血管并发症的关系。

导言本研究探讨了血糖监测系统使用者体内残余胆固醇、血糖指标与 1 型糖尿病慢性并发症之间的关系。结果共纳入 383 人，年龄为 48.3 ± 16.2 岁，女性占 54.1%，残余胆固醇水平为 16 ± 10 mg/dL。结果表明，残余胆固醇与在目标范围内的时间较少（P=.015）和超过目标范围的时间较多（P=.003）有关。糖尿病肾病是唯一与残余胆固醇水平超过 30 mg/dL 相关的并发症；OR：8.93；95% CI：2.99-26.62，P<.001。

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来源期刊

Revista clinica espanola 医学-医学：内科

CiteScore

4.40

自引率

6.90%

发文量

审稿时长

28 days

期刊介绍： Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI). The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Revista Clínica Española is subject to a thorough double blind review of the received articles written in Spanish or English. Nine issues are published each year, including mostly originals, reviews and consensus documents.