Cellular metabolism: A key player in cancer ferroptosis

IF 20.1 1区 医学 Q1 ONCOLOGY Cancer Communications Pub Date : 2024-01-13 DOI:10.1002/cac2.12519
Xianjie Jiang, Qiu Peng, Mingjing Peng, Linda Oyang, Honghan Wang, Qiang Liu, Xuemeng Xu, Nayiyuan Wu, Shiming Tan, Wenjuan Yang, Yaqian Han, Jinguan Lin, Longzheng Xia, Yanyan Tang, Xia Luo, Jie Dai, Yujuan Zhou, Qianjin Liao
{"title":"Cellular metabolism: A key player in cancer ferroptosis","authors":"Xianjie Jiang,&nbsp;Qiu Peng,&nbsp;Mingjing Peng,&nbsp;Linda Oyang,&nbsp;Honghan Wang,&nbsp;Qiang Liu,&nbsp;Xuemeng Xu,&nbsp;Nayiyuan Wu,&nbsp;Shiming Tan,&nbsp;Wenjuan Yang,&nbsp;Yaqian Han,&nbsp;Jinguan Lin,&nbsp;Longzheng Xia,&nbsp;Yanyan Tang,&nbsp;Xia Luo,&nbsp;Jie Dai,&nbsp;Yujuan Zhou,&nbsp;Qianjin Liao","doi":"10.1002/cac2.12519","DOIUrl":null,"url":null,"abstract":"<p>Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal. It produces energy, furnishes raw materials, and intermediates for biomolecule synthesis, and modulates enzyme activity to sustain normal cellular functions. Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions, including programmed cell death. Ferroptosis is a recently discovered form of iron-dependent programmed cell death. The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression. However, the role of cellular metabolism, particularly glucose and amino acid metabolism, in cancer ferroptosis is not well understood. Here, we reviewed glucose, lipid, amino acid, iron and selenium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process. Additionally, we provided a detailed overview of agents used to induce cancer ferroptosis. We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellular redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death, resulting in enhanced tumor cell killing. The combination of ferroptosis inducers and cellular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.</p>","PeriodicalId":9495,"journal":{"name":"Cancer Communications","volume":null,"pages":null},"PeriodicalIF":20.1000,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cac2.12519","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Communications","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cac2.12519","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal. It produces energy, furnishes raw materials, and intermediates for biomolecule synthesis, and modulates enzyme activity to sustain normal cellular functions. Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions, including programmed cell death. Ferroptosis is a recently discovered form of iron-dependent programmed cell death. The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression. However, the role of cellular metabolism, particularly glucose and amino acid metabolism, in cancer ferroptosis is not well understood. Here, we reviewed glucose, lipid, amino acid, iron and selenium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process. Additionally, we provided a detailed overview of agents used to induce cancer ferroptosis. We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellular redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death, resulting in enhanced tumor cell killing. The combination of ferroptosis inducers and cellular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
细胞新陈代谢:癌症铁变态反应的关键角色
细胞新陈代谢是细胞维持生长和自我更新的基本过程。它产生能量,为生物大分子合成提供原料和中间体,并调节酶的活性以维持正常的细胞功能。细胞新陈代谢是细胞生命过程的基础,在包括细胞程序性死亡在内的各种生物功能中发挥着调节作用。铁突变是最近发现的一种依赖铁的细胞程序性死亡形式。抑制铁跃迁在肿瘤发生和发展中起着至关重要的作用。然而,人们对细胞代谢,尤其是葡萄糖和氨基酸代谢在癌症铁凋亡中的作用还不甚了解。在此,我们回顾了葡萄糖、脂质、氨基酸、铁和硒代谢在癌细胞铁跃迁中的参与,以阐明不同代谢途径对这一过程的影响。此外,我们还详细介绍了用于诱导癌细胞铁变态反应的药物。我们解释说,肿瘤细胞的新陈代谢在维持细胞内氧化还原平衡方面起着至关重要的作用,破坏这些细胞的正常新陈代谢过程会使它们更容易受到铁诱导的细胞死亡的影响,从而增强对肿瘤细胞的杀伤力。铁氧化诱导剂和细胞代谢抑制剂的结合可能是未来癌症治疗的一种新方法,也是推动治疗方法发展的一种重要策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Cancer Communications
Cancer Communications Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
25.50
自引率
4.30%
发文量
153
审稿时长
4 weeks
期刊介绍: Cancer Communications is an open access, peer-reviewed online journal that encompasses basic, clinical, and translational cancer research. The journal welcomes submissions concerning clinical trials, epidemiology, molecular and cellular biology, and genetics.
期刊最新文献
Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms. Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling. Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Engineering heavy chain antibody-drug conjugates against solid tumors for a one-shot kill. Acquired RD3 loss regulates immune surveillance in high-risk and therapy defying progressive neuroblastoma.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1