S. S. Shilin, Y. I. Emets, E. A. Spirin, K. S. Gusev, A. A. Antonyan, A. S. Dolgonovskaya, D. V. Piskarev, V. I. Popadyuk, I. V. Kastyro, I. B. Ganshin, S. M. Vasyakova
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引用次数: 0
Abstract
Hypertrophy of the pharyngeal tonsil (HPT) is considered one of the most common diseases of the ENT organs. The aim of the present study was to investigate the role of interleukin 10 (IL-10) gene polymorphism and infections caused by human herpesviruses 6 (HHV6), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in children with HPT. The study included 106 children with HPT and 38 healthy children at the age from 2 to 11 years. All children with HPT were divided into three subgroups depending on the pharyngeal tonsil size. Viruses were determined by real-time quantitative polymerase chain reaction using commercially available kits (QIAGEN, Germany). In patients with HPT, HHV6 was more frequently detected as compared with CMV and EBV. Among the three subgroups of children with HPT, infections with HHV6 and EBV viruses predominated in children with a maximal degree of hypertrophy of the pharyngeal tonsil. The frequency of the IL-10 gene rs1800896 GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for this gene were detected in the subgroup of children with the lowest size of the pharyngeal tonsil as compared with other subgroups. We hypothesized that infections with HHV6 and EBV can contribute to an increase in the pharyngeal tonsil size. The IL-10 rs1800896 GG genotype can contribute to resistance to hypertrophy of the pharyngeal tonsil.
期刊介绍：
Molecular Genetics, Microbiology and Virology is a journal that covers most topical theoretical and applied problems of molecular genetics of pro- and eukaryotic organisms, molecular microbiology and molecular virology. An important part the journal assigns to investigations of the genetic apparatus of microorganisms, searching for forms of genetic exchange, genetic mapping of pathogenic causative agents, to ascertainment of the structure and functions of extrachromosomal factors of heredity and migratory genetic elements, to theoretical studies into the mechanisms of genetic regulation. The journal publishes results of research on molecular and genetic bases of an eukaryotic cell, functioning of chromosomes and chromatin, nature of genetic changes in malignization and a set of hereditary diseases. On the pages of the journal there is covered the formulation of molecular bases of virology including issues of integration of viral and cellular genomes, and issues of persistence. The journal plans to put materials on genetic engineering, envisaging synthesis and isolation of genes from natural reservoirs, creation of plasmid- and virus-based vector, production of recombinant DNA molecules, the creation of Gene Banks for Microbes, animals, and human; and also on biotechnological production of hormones, components of antiviral vaccines, diagnostic and therapeutic preparations.
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