Pierre Delanaye, Etienne Cavalier, Thomas Stehlé, Hans Pottel
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引用次数: 0
Abstract
Background: In daily practice, glomerular filtration rate (GFR) is estimated with equations including renal biomarkers. Among these biomarkers, serum creatinine remains the most used. However, there are many limitations with serum creatinine, which we will discuss in the current review. We will also discuss how creatinine-based equations have been developed and what we can expect from them in terms of performance to estimate GFR.
Summary: Different creatinine-based equations have been proposed. We will show the advantages of the recent European Kidney Function Consortium equation. This equation can be used in children and adults. This equation can also be used with some flexibility in different populations.
Key messages: GFR is estimated by creatinine-based equations, but the most important for nephrologists is probably to know the limitations of these equations.
背景：在日常实践中，肾小球滤过率（GFR）是通过包括肾脏生物标志物在内的方程进行估算的。在这些生物标志物中，血清肌酐仍然是最常用的。然而，血清肌酐存在许多局限性，我们将在本综述中加以讨论。我们还将讨论以血肌酐为基础的方程是如何开发出来的，以及我们可以期望它们在估算 GFR 方面有怎样的表现。我们将介绍最近推出的欧洲肾功能联盟（EKFC）方程的优点。该方程可用于儿童和成人。该方程还可在不同人群中灵活使用：关键信息：肾小球滤过率是通过基于肌酐的方程估算出来的，但对肾病学家来说，最重要的可能是了解这些方程的局限性。
期刊介绍：
''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.
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