The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions.

IF 2.2 4区医学 Q3 ONCOLOGY Cancer Biomarkers Pub Date : 2024-01-01 DOI:10.3233/CBM-230157

Xuan Zhang, Yang-Yang Wu, Yuan-Yuan Qin, Fa-Quan Lin

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Abstract

Objective: This article aims to investigate the clinical value of hemoglobin/red cell distribution width ratio (Hb/RDW), C-reactive protein/albumin ratio (CAR) and plateletcrit (PCT) combined with carcinoembryonic antigen (CEA) in colorectal cancer (CRC) auxiliary diagnosis.

Methods: We retrospectively analyzed in 718 subjects (212 with CRC, 209 with benign colorectal lesions (BCL), 111 with other cancers, and 186 healthy controls).

Results: The CAR, PCT, and CEA in the CRC group were higher than those in the BCL, other cancers, and the healthy control group. However, Hb/RDW in the CRC group was lower than the other three groups. Moreover, there were significant differences in Hb/RDW and CEA among different T-N-M stages (all P< 0.05). Multivariate logistic regression showed that low level of Hb/RDW and high level of CAR, CEA, PCT were risk factors for CRC, and are correlated with CRC stage. Additionally, the area under the receiver operating characteristic curve (AUC) of Hb/RDW+CEA (AUC: 0.735), CAR+CEA (AUC: 0.748), PCT+CEA (AUC: 0.807) was larger than that of Hb/RDW (AUC: 0.503), CAR (AUC: 0.614), or PCT (AUC: 0.713) alone (all P< 0.001) in distinguishing CRC from BCL.

Conclusions: Hb/RDW, CAR, PCT, and CEA are independent risk factors for CRC. Hb/RDW, CAR, and PCT combined with CEA have significant value for auxiliary differential diagnosis of CRC and BCL.

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血液学指标的联合检测可用于结直肠癌和良性结直肠病变的鉴别诊断。

研究目的本文旨在探讨血红蛋白/红细胞分布宽度比值（Hb/RDW）、C反应蛋白/白蛋白比值（CAR）和血小板比值（PCT）结合癌胚抗原（CEA）在结直肠癌（CRC）辅助诊断中的临床价值：我们对718名受试者（212名CRC患者、209名良性结直肠病变（BCL）患者、111名其他癌症患者和186名健康对照组）进行了回顾性分析：结果：CRC 组的 CAR、PCT 和 CEA 均高于 BCL、其他癌症和健康对照组。但 CRC 组的 Hb/RDW 低于其他三组。此外，Hb/RDW和CEA在不同的T-N-M分期之间存在明显差异（均P< 0.05）。多变量逻辑回归显示，低水平的 Hb/RDW 和高水平的 CAR、CEA、PCT 是 CRC 的危险因素，并与 CRC 分期相关。此外，在区分 CRC 和 BCL 方面，Hb/RDW+CEA（AUC：0.735）、CAR+CEA（AUC：0.748）、PCT+CEA（AUC：0.807）的接收者操作特征曲线下面积（AUC）均大于 Hb/RDW（AUC：0.503）、CAR（AUC：0.614）或 PCT（AUC：0.713）（均 P<0.001）：结论：Hb/RDW、CAR、PCT 和 CEA 是 CRC 的独立危险因素。结论：Hb/RDW、CAR、PCT 和 CEA 是 CRC 的独立危险因素，Hb/RDW、CAR 和 PCT 与 CEA 结合使用对辅助鉴别诊断 CRC 和 BCL 有重要价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Biomarkers ONCOLOGY-

CiteScore

5.20

自引率

3.20%

发文量

195

审稿时长

3 months

期刊介绍： Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.