Partial hydatidiform mole and coexisting fetus after frozen embryo transplantation: a case report.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI:10.5935/1518-0557.20230069
Jinran Li, Xiaoli Sun
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Abstract

Hydatidiform mole and coexisting fetus is a very rare condition of which etiology is still inconclusive. It may occur after assisted reproduction, often leading to the death of normal embryos and other serious complications. We report a case of partial hydatidiform mole and coexisting fetus after frozen embryo transplantation. More than two months after the patient underwent transplantation with two blastocysts (scored 4AB and 4BC), B-ultrasound showed a single live fetus with a large dense dotted strong echo area. The patient was treated with chemotherapy after the termination of pregnancy due to persistently increased human chorionic gonadotropin levels. Many studies have described trophoblast quality as a strong predictor of pregnancy. In the case in question, in addition to partial hydatidiform mole caused by multiple sperm entering the egg, we also speculate that the condition may be related to the poor quality of the trophoblastic ectoderm of the transferred embryo. In the process of assisted reproduction, the transfer of embryos with poor trophoblastic ectoderm in multiple embryo transfers may adversely affect pregnancy outcomes.

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冷冻胚胎移植后部分水胎记和并存胎儿:病例报告。
水样痣和并存胎儿是一种非常罕见的病症,其病因至今尚无定论。它可能在辅助生殖后发生,往往导致正常胚胎死亡和其他严重并发症。我们报告了一例冷冻胚胎移植后部分水滴形痣和并存胎儿的病例。患者在接受两个囊胚(评分为 4AB 和 4BC)移植手术两个多月后,B 超显示有一个单活胎儿,并伴有大片密集的点状强回声区。由于人绒毛膜促性腺激素水平持续升高,患者在终止妊娠后接受了化疗。许多研究认为滋养细胞质量是预测妊娠的重要指标。在本病例中,除了多个精子进入卵子导致部分水样痣外,我们还推测这种情况可能与移植胚胎的滋养层外胚层质量差有关。在辅助生殖过程中,多胚胎移植中滋养细胞外胚层质量差的胚胎可能会对妊娠结局产生不利影响。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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