Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI:10.5935/1518-0557.20230068

Paula Almeida Galvão Ferreira, Luiz Augusto Giordano, Luiz Felipe Bittencourt

{"title":"Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction.","authors":"Paula Almeida Galvão Ferreira, Luiz Augusto Giordano, Luiz Felipe Bittencourt","doi":"10.5935/1518-0557.20230068","DOIUrl":null,"url":null,"abstract":"Objective: To evaluate the efficacy of sublingually administered human chorionic gonadotropin (HCG) in combination with clomiphene citrate (CC) or letrozole (LTZ) for ovulation induction.Methods: In this prospective, double-blind, randomized study, the patients were divided into two placebo groups and two intervention groups using CC, LTZ, and HCG.Results: There were no statistically significant differences in ovulation induction between the groups. We compared endometrial thickness at the beginning of the cycle and during the pre-ovulatory period, and detected a moderately positive correlation when CC was administered with HCG.Conclusions: Sublingual HCG with CC caused a moderately positive correlation with endometrial thickening when compared with that at the beginning of the cycle and during the pre-ovulatory period. There was no significant change in the number of pre-ovulatory follicles.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"13-20"},"PeriodicalIF":1.8000,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936914/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jornal Brasileiro de Reproducao Assistida","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5935/1518-0557.20230068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To evaluate the efficacy of sublingually administered human chorionic gonadotropin (HCG) in combination with clomiphene citrate (CC) or letrozole (LTZ) for ovulation induction.

Methods: In this prospective, double-blind, randomized study, the patients were divided into two placebo groups and two intervention groups using CC, LTZ, and HCG.

Results: There were no statistically significant differences in ovulation induction between the groups. We compared endometrial thickness at the beginning of the cycle and during the pre-ovulatory period, and detected a moderately positive correlation when CC was administered with HCG.

Conclusions: Sublingual HCG with CC caused a moderately positive correlation with endometrial thickening when compared with that at the beginning of the cycle and during the pre-ovulatory period. There was no significant change in the number of pre-ovulatory follicles.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

舌下含服人类绒毛膜促性腺激素作为诱导排卵的辅助剂。

目的评估舌下含服人绒毛膜促性腺激素（HCG）与枸橼酸氯米芬（CC）或来曲唑（LTZ）联合诱导排卵的疗效：在这项前瞻性、双盲、随机研究中，患者被分为两个安慰剂组和两个使用CC、LTZ和HCG的干预组：结果：两组在诱导排卵方面无明显统计学差异。我们比较了周期开始时和排卵前期的子宫内膜厚度，发现当 CC 与 HCG 同时使用时，两者呈中度正相关：结论：与周期开始时和排卵前期相比，舌下含服 HCG 和 CC 与子宫内膜增厚呈中度正相关。排卵前卵泡数量无明显变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Jornal Brasileiro de Reproducao Assistida OBSTETRICS & GYNECOLOGY-

CiteScore

3.30

自引率

6.70%

发文量