Application of Suggestive Biomarkers in Dementia With Lewy Bodies With Masking of Typical Clinical Symptoms by Alzheimer Disease-type Pathology.

IF 1.4 4区医学 Q3 CLINICAL NEUROLOGY Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-17 DOI:10.1097/WAD.0000000000000597

Ryota Kobayashi, Daichi Morioka, Shinobu Kawakatsu, Kazutaka Sakamoto, Akihito Suzuki

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Abstract

Dementia with Lewy bodies (DLB) is strongly associated with Alzheimer disease (AD)-type pathology and tends to mask the core clinical features of DLB. Therefore, there may be cases of undiagnosed DLB without suggestive biomarkers of DLB. We describe the case of a 63-year-old woman who was initially diagnosed as having AD and later diagnosed with DLB based on suggestive biomarkers of DLB. In this case, transient sleep talking with physical movements for several days led to the assessment of suggestive biomarkers for DLB in the absence of the core clinical features of DLB. For clinicians, diagnosing DLB in patients with AD-type pathology is challenging. However, the application of biomarkers suggestive of DLB to all patients with dementia is not realistic. To overcome the difficulties of clinical diagnosis of DLB, further research is needed regarding strategies for the application of suggestive biomarkers for DLB to appropriately diagnose DLB.

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在路易体痴呆症中应用提示性生物标记物，阿尔茨海默病类型病理掩盖了典型临床症状。

路易体痴呆（DLB）与阿尔茨海默病（AD）型病理密切相关，往往会掩盖 DLB 的核心临床特征。因此，可能会有一些未确诊的 DLB 病例，但却没有 DLB 的提示性生物标志物。我们描述了一名 63 岁女性的病例，她最初被诊断为 AD，后来根据 DLB 的提示性生物标志物被诊断为 DLB。在这个病例中，由于连续数天出现伴有肢体运动的短暂梦呓，因此在缺乏 DLB 核心临床特征的情况下，我们评估了 DLB 的提示性生物标志物。对临床医生来说，诊断患有 AD 型病理的患者是否患有 DLB 具有挑战性。然而，将提示 DLB 的生物标志物应用于所有痴呆症患者是不现实的。为了克服临床诊断DLB的困难，需要进一步研究应用DLB提示性生物标志物的策略，以适当诊断DLB。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.