Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance.

Diabetes & vascular disease research Pub Date : 2024-01-01 DOI:10.1177/14791641241228156

Yang Zhao, Mengmeng Zhou, Yongfang Shang, Mei Dou, Shan Gao, Hai Yang, Fanghua Zhang

{"title":"Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance.","authors":"Yang Zhao, Mengmeng Zhou, Yongfang Shang, Mei Dou, Shan Gao, Hai Yang, Fanghua Zhang","doi":"10.1177/14791641241228156","DOIUrl":null,"url":null,"abstract":"Purpose: To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR).Methods: 120 individuals with IGT and IR were randomly divided into four groups treated with (1) chromium, (2) magnesium, (3) chromium and magnesium or (4) placebo. Metabolic and inflammatory indicators were measured at baseline and after 3 months intervention.Results: Comparison among groups showed that fasting plasma glucose (FPG), 2 h post glucose (2hPPG), fasting insulin (FINS) and homeostatic model assessment for insulin resistance (HOMA-IR) in Cr + Mg group were significantly decreased compared with the other three groups (p < .05), and high density lipoprotein (HDL-c) levels were higher. 8-iso prostaglandin F2 alpha (8-iso-PGF2a) decreased in Cr, Mg, and Cr + Mg groups compared with placebo (p < .05), and 8-iso-PGF2a decreased in Cr + Mg groups compared with Cr group and Mg groups (p > .05). Intra-group comparison showed that the levels of FPG, 2hPPG and FINS in Cr + Mg group were significantly decreased after intervention (p < .05), and FINS in Mg group was significantly decreased (p < .01). The levels of HDL-c and triacylglycerol (TG) in Cr + Mg group were significantly improved (p < .05). The level of HDL-c in Mg group was significantly improved compared with baseline (p < .05). Compared with baseline, high-sensitivity C-reactive protein (hsCRP) levels in Cr + Mg group and Mg group were significantly decreased (p < .05).Conclusions: The co-supplementation of Cr and Mg improves glycemic and lipid levels and reduces the inflammatory response and oxidative stress profiles of individuals with impaired glucose tolerance and insulin resistance.","PeriodicalId":93978,"journal":{"name":"Diabetes & vascular disease research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10798099/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & vascular disease research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/14791641241228156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, and oxidative stress with impaired glucose tolerance (IGT) and insulin resistance (IR).

Methods: 120 individuals with IGT and IR were randomly divided into four groups treated with (1) chromium, (2) magnesium, (3) chromium and magnesium or (4) placebo. Metabolic and inflammatory indicators were measured at baseline and after 3 months intervention.

Results: Comparison among groups showed that fasting plasma glucose (FPG), 2 h post glucose (2hPPG), fasting insulin (FINS) and homeostatic model assessment for insulin resistance (HOMA-IR) in Cr + Mg group were significantly decreased compared with the other three groups (p < .05), and high density lipoprotein (HDL-c) levels were higher. 8-iso prostaglandin F2 alpha (8-iso-PGF2a) decreased in Cr, Mg, and Cr + Mg groups compared with placebo (p < .05), and 8-iso-PGF2a decreased in Cr + Mg groups compared with Cr group and Mg groups (p > .05). Intra-group comparison showed that the levels of FPG, 2hPPG and FINS in Cr + Mg group were significantly decreased after intervention (p < .05), and FINS in Mg group was significantly decreased (p < .01). The levels of HDL-c and triacylglycerol (TG) in Cr + Mg group were significantly improved (p < .05). The level of HDL-c in Mg group was significantly improved compared with baseline (p < .05). Compared with baseline, high-sensitivity C-reactive protein (hsCRP) levels in Cr + Mg group and Mg group were significantly decreased (p < .05).

Conclusions: The co-supplementation of Cr and Mg improves glycemic and lipid levels and reduces the inflammatory response and oxidative stress profiles of individuals with impaired glucose tolerance and insulin resistance.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

共同补充铬和镁对糖耐量受损患者代谢概况、炎症和氧化应激的影响

目的：评估铬（Cr）和镁（Mg）离子对糖耐量受损（IGT）和胰岛素抵抗（IR）患者的代谢概况、炎症和氧化应激的影响。方法：将120名糖耐量受损和胰岛素抵抗患者随机分为四组，分别接受(1)铬、(2)镁、(3)铬和镁或(4)安慰剂治疗。分别在基线期和干预 3 个月后测量代谢和炎症指标：各组间的比较显示，铬+镁组的空腹血浆葡萄糖（FPG）、血糖后 2 小时血糖（2hPPG）、空腹胰岛素（FINS）和胰岛素抵抗静态模型评估（HOMA-IR）与其他三组相比明显下降（P .05），高密度脂蛋白（HDL-c）水平升高。与安慰剂相比，Cr 组、Mg 组和 Cr + Mg 组的 8-iso 前列腺素 F2 alpha（8-iso-PGF2a）下降（p < .05），而与 Cr 组和 Mg 组相比，Cr + Mg 组的 8-iso-PGF2a 下降（p > .05）。组内比较显示，干预后，Cr + Mg 组的 FPG、2hPPG 和 FINS 水平显著下降（P .05），Mg 组的 FINS 水平显著下降（P .01）。Cr + Mg 组的 HDL-c 和三酰甘油（TG）水平明显改善（P .05）。与基线相比，镁组的 HDL-c 水平明显提高（P .05）。与基线相比，Cr + Mg 组和 Mg 组的高敏 C 反应蛋白（hsCRP）水平明显下降（p .05）：共同补充铬和镁可改善糖耐量受损和胰岛素抵抗患者的血糖和血脂水平，降低炎症反应和氧化应激特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Diabetes & vascular disease research

自引率

0.00%

发文量