Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM BMJ Open Diabetes Research & Care Pub Date : 2024-01-01 DOI:10.1136/bmjdrc-2023-003744
Chikako Inoue, Yoshiki Kusunoki, Mana Ohigashi, Keiko Osugi, Kazuhiro Kitajima, Ayako Takagi, Maki Inoue, Chisako Yagi, Taku Tsunoda, Miki Kakutani, Manabu Kadoya, Kosuke Konishi, Tomoyuki Katsuno, Hidenori Koyama
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Abstract

Introduction Although type 2 diabetes mellitus (T2DM) is associated with alterations in brain structure, the relationship between glycemic control indices and brain imaging markers remains unclear. This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic control indices and brain imaging biomarkers assessed by MRI. Research design and methods This cross-sectional study included 150 patients with T2DM. The severity of cerebral white matter lesions (WMLs) was assessed using MRI for deep and subcortical white matter and periventricular hyperintensities. The degree of medial temporal lobe atrophy (MTA) was assessed using voxel-based morphometry. Each participant wore a retrospective CGM for 14 consecutive days, and glycemic control indices, such as time in range (TIR) and glycemia risk index (GRI), were calculated. Results The proportion of patients with severe WMLs showed a decreasing trend with increasing TIR ( P for trend=0.006). The proportion of patients with severe WMLs showed an increasing trend with worsening GRI ( P for trend=0.011). In contrast, no significant association was observed between the degree of MTA and CGM-derived glycemic control indices, including TIR ( P for trend=0.325) and GRI ( P for trend=0.447). Conclusions The findings of this study indicate that the severity of WMLs is associated with TIR and GRI, which are indices of the quality of glycemic control. Trial registration number UMIN000032143. Data are available upon reasonable request. The individual de-identified participant data will be shared with the corresponding author upon reasonable request.
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日本 2 型糖尿病患者脑成像生物标志物与连续血糖监测得出的血糖控制指数之间的关系
导言:尽管2型糖尿病(T2DM)与大脑结构的改变有关,但血糖控制指数与大脑成像标志物之间的关系仍不清楚。本研究旨在探讨连续血糖监测(CGM)得出的血糖控制指数与核磁共振成像评估的脑成像生物标志物之间的关系。研究设计和方法 这项横断面研究纳入了 150 名 T2DM 患者。脑白质病变(WMLs)的严重程度是通过核磁共振成像对深部和皮层下白质以及脑室周围高密度进行评估的。内侧颞叶萎缩(MTA)的程度则通过基于体素的形态测量进行评估。每位参与者连续 14 天佩戴回顾性 CGM,并计算血糖控制指数,如在量程内的时间(TIR)和血糖风险指数(GRI)。结果 随着 TIR 的增加,严重 WML 患者的比例呈下降趋势(趋势值=0.006)。随着 GRI 的恶化,重度 WMLs 患者的比例呈上升趋势(趋势值=0.011)。相比之下,MTA 的程度与 CGM 衍生的血糖控制指数(包括 TIR ( 趋势值=0.325) 和 GRI ( 趋势值=0.447))之间并无明显关联。结论 本研究结果表明,WMLs 的严重程度与 TIR 和 GRI(血糖控制质量指标)相关。试验注册号为 UMIN000032143。如有合理要求,可提供数据。如提出合理要求,我们将与通讯作者共享去标识化的参与者个人数据。
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来源期刊
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
9.30
自引率
2.40%
发文量
123
审稿时长
18 weeks
期刊介绍: BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of high-quality — and evidence-based — original research articles.
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