Advances in nanotechnology-assisted photodynamic therapy for neurological disorders: a comprehensive review.

IF 4.5 3区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2024-12-01 Epub Date: 2024-01-18 DOI:10.1080/21691401.2024.2304814

Abdul Nasir, Mujeeb Ur Rehman, Tamreez Khan, Mansoor Husn, Manzar Khan, Ahmad Khan, Abdifatah Mohamed Nuh, Wei Jiang, Hafiz Muhammad Umer Farooqi, Qain Bai

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Abstract

Neurological disorders such as neurodegenerative diseases and nervous system tumours affect more than one billion people throughout the globe. The physiological sensitivity of the nervous tissue limits the application of invasive therapies and leads to poor treatment and prognosis. One promising solution that has generated attention is Photodynamic therapy (PDT), which can potentially revolutionise the treatment landscape for neurological disorders. PDT attracted substantial recognition for anticancer efficacy and drug conjugation for targeted drug delivery. This review thoroughly explained the basic principles of PDT, scientific interventions and advances in PDT, and their complicated mechanism in treating brain-related pathologies. Furthermore, the merits and demerits of PDT in the context of neurological disorders offer a well-rounded perspective on its feasibility and challenges. In conclusion, this review encapsulates the significant potential of PDT in transforming the treatment landscape for neurological disorders, emphasising its role as a non-invasive, targeted therapeutic approach with multifaceted applications.

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纳米技术辅助光动力疗法治疗神经系统疾病的进展：综述。

神经退行性疾病和神经系统肿瘤等神经系统疾病影响着全球十多亿人。神经组织的生理敏感性限制了侵入性疗法的应用，导致治疗效果和预后不佳。光动力疗法（PDT）是一种前景广阔的解决方案，它有可能彻底改变神经系统疾病的治疗格局，因而备受关注。光动力疗法在抗癌疗效和药物共轭靶向给药方面获得了广泛认可。这篇综述全面阐述了光导疗法的基本原理、科学干预措施、光导疗法的进展及其治疗脑相关病症的复杂机制。此外，PDT 在神经系统疾病中的优缺点为其可行性和挑战提供了一个全面的视角。总之，这篇综述概括了光动力疗法在改变神经系统疾病治疗格局方面的巨大潜力，强调了它作为一种非侵入性、靶向治疗方法在多方面应用中的作用。

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来源期刊

Artificial Cells, Nanomedicine, and Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ENGINEERING, BIOMEDICAL

CiteScore

10.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Artificial Cells, Nanomedicine and Biotechnology covers the frontiers of interdisciplinary research and application, combining artificial cells, nanotechnology, nanobiotechnology, biotechnology, molecular biology, bioencapsulation, novel carriers, stem cells and tissue engineering. Emphasis is on basic research, applied research, and clinical and industrial applications of the following topics:artificial cellsblood substitutes and oxygen therapeuticsnanotechnology, nanobiotecnology, nanomedicinetissue engineeringstem cellsbioencapsulationmicroencapsulation and nanoencapsulationmicroparticles and nanoparticlesliposomescell therapy and gene therapyenzyme therapydrug delivery systemsbiodegradable and biocompatible polymers for scaffolds and carriersbiosensorsimmobilized enzymes and their usesother biotechnological and nanobiotechnological approachesRapid progress in modern research cannot be carried out in isolation and is based on the combined use of the different novel approaches. The interdisciplinary research involving novel approaches, as discussed above, has revolutionized this field resulting in rapid developments. This journal serves to bring these different, modern and futuristic approaches together for the academic, clinical and industrial communities to allow for even greater developments of this highly interdisciplinary area.