A novel methodology to demonstrate vestibulo-ocular reflex using caloric stimulation in undergraduate physiology laboratory.

IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES Advances in Physiology Education Pub Date : 2024-06-01 Epub Date: 2024-01-18 DOI:10.1152/advan.00065.2022
Aditya Dontham, Abhijith K Anil, Nasreen Akhtar, Kishore K Deepak
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Abstract

The study aims to develop a novel methodology to demonstrate the vestibulo-ocular reflex (VOR) and nystagmus by caloric stimulation in an undergraduate medical physiology laboratory. The experimental setup involved two sets of electrodes: one set positioned laterally to both eyes, and another set positioned vertically over either the right or left eye. The caloric method is used to stimulate ears, which involves irrigation of warm (44°C) and cold (30°C) water into the ears while maintaining a temperature difference of approximately ±7°C from the body temperature. The changes in chorioretinal potential were calibrated to angular displacement by a two-point calibration method, and angular velocity was derived after taking the first-time derivative. The results obtained from the digital data acquisition system were compared to the traditional instrument used in our Otorhinolaryngology Department [Interacoustics Videonystagmography (VNG) System for hospitals, medical grade] for the normal subject's data. No significant differences in angular velocity were noted (P > 0.05). The cold stimuli elicit a more pronounced VOR compared to the warm stimuli. It has been consistently observed that the onset of nystagmus occurs approximately 20 s after irrigation, reaching its peak intensity between 45 and 90 s, and gradually diminishing until it ceases after approximately 200 s. Our developed methodology enables the recording and quantification of nystagmus using easily accessible equipment. This study serves the goal of visualizing the physiological process of VOR and thereby fulfills the goal of an effective teaching tool for demonstrating to undergraduate medical students.NEW & NOTEWORTHY We developed a novel methodology to demonstrate and visualize the most common and important physiological phenomenon like the vestibulo-ocular reflex as a teaching module for undergraduate students.

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在本科生生理学实验室利用热量刺激演示前庭眼反射的新方法。
研究目的:本研究旨在开发一种新方法,在本科生医学生理学实验室中通过热量刺激来演示前庭-眼球反射(VOR)和眼球震颤:实验装置包括两组电极:一组放置在双眼侧面,另一组垂直放置在右眼或左眼上。采用热量法刺激耳朵,即向耳朵灌注温水(44 °C)和冷水(30 °C),同时与体温保持约 +/- 7 °C的温差。角膜视网膜电位的变化通过两点校准法校准为角位移,角速度则通过求一次导数得出:主要结果:数字数据采集系统获得的结果与耳鼻喉科使用的传统仪器(Interacoustics Videonystagmography VNG 系统,医院用,医疗级)获得的正常受试者数据进行了比较。角速度无明显差异(P>0.05)。与温刺激相比,冷刺激引起的 VOR 更明显。据一致观察,眼球震颤在灌流后约 20 秒开始,在 45 至 90 秒之间达到峰值强度,然后逐渐减弱,直至约 200 秒后停止:结论:我们所开发的方法可利用易于获取的设备记录和量化眼球震颤。这项研究达到了将 VOR 生理过程可视化的目的,从而实现了为医学本科生提供有效教学工具的目标。
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来源期刊
CiteScore
3.40
自引率
19.00%
发文量
100
审稿时长
>12 weeks
期刊介绍: Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms. Submissions that evaluate new technologies for teaching and research, and educational pedagogy, are especially welcome. The audience for the journal includes educators at all levels: K–12, undergraduate, graduate, and professional programs.
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