SARS-CoV-2-Virus structure and life cycle.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-01-04 DOI:10.1016/bs.pmbts.2023.09.001
Sameer Saleem Tebha, Aimen Tameezuddin, Sanchit Bajpai, Asiya Kamber Zaidi
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Abstract

This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics and diversity of coronaviruses, particularly SARS-CoV-2, highlighting its similarities with other beta-coronaviruses. The replication and transcription complex, RNA elongation, and capping, as well as the role of accessory proteins in viral replication and modulation of the host immune response is discussed extensively.

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SARS-CoV-2 病毒的结构和生命周期。
本书简明扼要地概述了导致 COVID-19 大流行的 SARS-CoV-2 病毒。它探讨了基于形态和核酸组成的病毒分类(重点是 DNA 和 RNA 病毒)、SARS-CoV-2 的结构(包括结构蛋白和非结构蛋白的细节)以及病毒复制机制。然后,本章深入探讨了冠状病毒,特别是 SARS-CoV-2 的特征和多样性,强调了它与其他β-冠状病毒的相似之处。本章广泛讨论了复制和转录复合体、RNA 延长和封顶,以及辅助蛋白在病毒复制和调节宿主免疫反应中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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