Relation between vitamin D and adolescents' serum prolactin.

IF 2.5 Q2 OBSTETRICS & GYNECOLOGY Przeglad Menopauzalny Pub Date : 2023-12-01 Epub Date: 2023-12-21 DOI:10.5114/pm.2023.133883

Ainur Amanzholkyzy, Ainur Donayeva, Dinara Kulzhanova, Ibrahim A Abdelazim, Talgar Abilov, Zhenisbek Baubekov, Ihab I Samaha

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Abstract

Introduction: To detect whether there is a relation between vitamin D (Vit. D) and adolescents' serum prolactin (PRL) or not.

Material and methods: Hundred and seventy-six adolescent girls were recruited for the current study, which was conducted in West Kazakhstan (Aktobe) over two years. After thorough evaluation, blood samples were taken from adolescents to measure thyroid stimulating hormone (TSH), free thyroxine (T4), PRL, glycosylated hemoglobin and 25(OH)D. The studied adolescents were classified into study group [25(OH)D deficient] and controls [normal 25(OH)D]. The acquired adolescents' variables were analyzed using the Student t-test and Pearson's correlation.

Results: The serum TSH and PRL were statistically higher in the study group than normal controls (3.73 ±1.45 mIU/ml and 47.5 ±7.6 ng/ml vs. 2.67 ±1.0 and 10.8 ±5.1, respectively), (p = 0.0003 and p = 0.0001, respectively). The free T4 was statistically lower in the study group than normal controls (1.4 ±0.6 ng/ml vs. 1.5 ±0.4), (p = 0.0001). Strong negative associations between the serum PRL and 25(OH)D [r = -0.803 (p < 0.00001)], and between the serum PRL and free T4 [r = -0.6959 (p < 0.00001)] were detected in this study. Additionally, there was a strong positive association between the serum PRL and TSH [r = 0.8137 (p < 0.00001)].

Conclusions: A strong negative association between the serum PRL and 25(OH)D and a strong positive association between the serum PRL and TSH were detected in this study. This study recommends further studies to confirm the relation between Vit. D and PRL and screening Vit. D deficient adolescents for PRL and thyroid disorders.

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维生素 D 与青少年血清催乳素之间的关系。

引言材料与方法：本研究在西哈萨克斯坦（阿克托别）进行，为期两年，共招募了 176 名少女。经过全面评估后，对青少年进行了血液样本采集，以测量促甲状腺激素（TSH）、游离甲状腺素（T4）、PRL、糖化血红蛋白和 25（OH）D。被研究的青少年被分为研究组[25（OH）D 缺乏]和对照组[25（OH）D 正常]。采用学生 t 检验和 Pearson 相关性对所获青少年变量进行分析：研究组的血清促甲状腺激素（TSH）和促肾上腺皮质激素（PRL）在统计学上高于正常对照组（分别为 3.73 ±1.45 mIU/ml 和 47.5 ±7.6 ng/ml vs. 2.67 ±1.0 和 10.8 ±5.1），（分别为 p = 0.0003 和 p = 0.0001）。据统计，研究组的游离 T4 低于正常对照组（1.4 ±0.6 ng/ml vs. 1.5 ±0.4），（p = 0.0001）。本研究发现，血清PRL与25（OH）D之间[r = -0.803 (p < 0.00001)]以及血清PRL与游离T4之间[r = -0.6959 (p < 0.00001)]存在很强的负相关。此外，血清PRL与促甲状腺激素之间存在很强的正相关性[r = 0.8137 (p < 0.00001)]：结论：本研究发现血清 PRL 与 25(OH)D 呈强负相关，血清 PRL 与 TSH 呈强正相关。本研究建议开展进一步研究，以确认维生素 D 与 PRL 之间的关系，并筛查维生素 D 缺乏的青少年是否患有 PRL 和甲状腺疾病。

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