Hypersensitivity Pneumonitis: Challenges of a Complex Disease

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM Canadian respiratory journal Pub Date : 2024-01-18 DOI:10.1155/2024/4919951
Diana Calaras, Aliona David, Eirini Vasarmidi, Katerina Antoniou, Alexandru Corlateanu
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Abstract

Hypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of inciting antigens causing hypersensitivity pneumonitis have been found to cover a wide range of occupations. As working practices have changed over time, especially in industrialized countries, new names for occupational HP have emerged. This review emphasizes the main diagnostic issues arising from the high variability of clinical presentation and the broad spectrum of causal antigens. Furthermore, it provides an overview of current methods to unveil possible causes of hypersensitivity pneumonitis, highlights HP’s current diagnostic and treatment challenges and the remaining areas of uncertainty, and presents prevention strategies.
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超敏性肺炎:复杂疾病的挑战
超敏性肺炎(HP)是一种复杂的间质性肺部疾病,由易感人群和致敏人群长期吸入多种抗原引起,通常与职业接触有关。引起超敏性肺炎的诱发抗原种类繁多,涉及多种职业。随着时间的推移,特别是在工业化国家,工作方式发生了变化,职业性高过敏性肺炎也出现了新的名称。本综述强调了临床表现的高度可变性和致病抗原的广泛性所带来的主要诊断问题。此外,它还概述了目前揭示超敏性肺炎可能病因的方法,强调了职业性高血压目前在诊断和治疗方面面临的挑战以及尚存在的不确定领域,并介绍了预防策略。
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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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