The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-01-17 DOI:10.1016/j.peptides.2024.171154
Zhineng Liu , Keyi Nong , Xinyun Qin , Xin Fang , Bin Zhang , Wanyan Chen , Zihan Wang , Yijia Wu , Huiyu Shi , Xuemei Wang , Youming Liu , Qingfeng Guan , Haiwen Zhang
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Abstract

Abaecin is a natural antimicrobial peptide (AMP) rich in proline from bees. It is an important part of the innate humoral immunity of bees and has broad-spectrum antibacterial ability. This study aimed to determine the effect of Abaecin on dextran sulfate sodium (DSS) -induced ulcerative colitis (UC) in mice and to explore its related mechanisms. Twenty-four mice with similar body weight were randomly divided into 4 groups. 2.5% DSS was added to drinking water to induce colitis in mice. Abaecin and PBS were administered rectally on the third, fifth, and seventh days of the experimental period. The results showed that Abaecin significantly alleviated histological damage and intestinal mucosal barrier damage caused by colitis in mice, reduced the concentration of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, IFN-γ, and the phosphorylation of NF-κB / MAPK inflammatory signaling pathway proteins, and improved the composition of intestinal microorganisms. These findings suggest that Abaecin may have potential prospects for the treatment of UC.

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抗菌肽阿贝金通过调节炎症信号通路和肠道微生物组成缓解小鼠结肠炎。
阿贝金是一种天然抗菌肽(AMP),富含来自蜜蜂的脯氨酸。它是蜜蜂先天体液免疫的重要组成部分,具有广谱抗菌能力。本研究旨在确定阿贝金对右旋糖酐硫酸钠(DSS)诱导的小鼠溃疡性结肠炎(UC)的影响,并探讨其相关机制。24只体重相近的小鼠被随机分为4组。在饮用水中加入 2.5% DSS 诱导小鼠结肠炎。在实验期的第三、第五和第七天,分别直肠给予阿贝金和 PBS。结果表明,阿贝金能明显减轻小鼠结肠炎引起的组织学损伤和肠粘膜屏障损伤,降低促炎细胞因子 IL-1β、IL-6、TNF-α、IFN-γ 的浓度和 NF-κB / MAPK 炎症信号通路蛋白的磷酸化,并改善肠道微生物的组成。这些研究结果表明,阿贝金可能具有治疗 UC 的潜在前景。
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来源期刊
Peptides
Peptides 医学-生化与分子生物学
CiteScore
6.40
自引率
6.70%
发文量
130
审稿时长
28 days
期刊介绍: Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.
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