Unveiling mortality risk factors in paediatric sickle cell disease patients during acute crises in the Democratic Republic of the Congo

IF 2.1 4区 医学 Q3 HEMATOLOGY Blood Cells Molecules and Diseases Pub Date : 2024-01-20 DOI:10.1016/j.bcmd.2024.102828
Paul Muteb Boma , Stéphanie Luntadila Ngimbi , Junior Makiese Kindundu , Jean Israël Wela , Nathalie Lukanke Ngoie , Valentin Mukeba Ngwamah , Sandra Mbuyi Tshiswaka , Joséphine Kalenga Monga , Jules Mulefu Panda , Bruno Bonnechère
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Abstract

Sickle cell disease (SCD) is a significant health burden in the Democratic Republic of the Congo (DRC). This study aims to identify predictive factors of mortality in SCD children admitted to emergency care in Lubumbashi, DRC. We performed a non-interventional cohort follow-up on SCD patients aged 0 to 16 admitted for a “true emergency”. Demographic, clinical, and biological data were collected. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors associated with mortality. Among the 121 patients included, 24 died during the follow-up period. Univariate regression revealed age, Mikobi score, referral origin, stroke, and severe infection as significant risk factors. Multivariate analyses identified Hb, WBC, SR, and LDH as predictive factors of mortality. Notably, patients aged 12 to 16 years faced a higher risk, shifting the age of mortality from early to late childhood and adolescence. This study provides valuable insights into mortality risk factors for paediatric SCD patients during acute crises. Early diagnosis, regular follow-up, and therapeutic education are essential to improve patient outcomes and survival rates. These findings contribute to better disease management and targeted interventions, aiming to reduce mortality associated with SCD.

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揭示刚果民主共和国急性危机期间小儿镰状细胞病患者的死亡风险因素
镰状细胞病(SCD)是刚果民主共和国(DRC)的一项重大健康负担。本研究旨在确定刚果(金)卢本巴希市急诊收治的镰状细胞病儿童的死亡率预测因素。我们对因 "真正的急诊 "入院的 0-16 岁 SCD 患者进行了非干预性队列随访。我们收集了人口统计学、临床和生物学数据。我们进行了单变量和多变量逻辑回归分析,以确定与死亡率相关的重要风险因素。在纳入的 121 名患者中,有 24 人在随访期间死亡。单变量回归显示,年龄、米科比评分、转诊来源、中风和严重感染是重要的风险因素。多变量分析发现,Hb、WBC、SR 和 LDH 是预测死亡率的因素。值得注意的是,12 至 16 岁的患者面临的风险更高,从而将死亡年龄从儿童早期转移到晚期和青春期。这项研究为了解急性危重症期间儿科 SCD 患者的死亡风险因素提供了宝贵的见解。早期诊断、定期随访和治疗教育对于改善患者预后和提高存活率至关重要。这些发现有助于更好地进行疾病管理和有针对性的干预,从而降低与 SCD 相关的死亡率。
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
42
审稿时长
14 days
期刊介绍: Blood Cells, Molecules & Diseases emphasizes not only blood cells, but also covers the molecular basis of hematologic disease and studies of the diseases themselves. This is an invaluable resource to all those interested in the study of hematology, cell biology, immunology, and human genetics.
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