Update: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas

IF 6.9 2区 医学 Q1 HEMATOLOGY Blood Reviews Pub Date : 2024-01-20 DOI:10.1016/j.blre.2024.101172
H. Witte , A. Künstner , N. Gebauer
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引用次数: 0

Abstract

The vast spectrum of aggressive B-cell non-Hodgkin neoplasms (B-NHL) encompasses several infrequent entities occurring in association with viral infections, posing diagnostic challenges for practitioners. In the emerging era of precision oncology, the molecular characterization of malignancies has acquired paramount significance. The pathophysiological comprehension of specific entities and the identification of targeted therapeutic options have seen rapid development. However, owing to their rarity, not all entities have undergone exhaustive molecular characterization.

Considerable heterogeneity exists in the extant body of work, both in terms of employed methodologies and the scale of cases studied. Presently, therapeutic strategies are predominantly derived from observations in diffuse large B-cell lymphoma (DLBCL), the most prevalent subset of aggressive B-NHL. Ongoing investigations into the molecular profiles of these uncommon virus-associated entities are progressively facilitating a clearer distinction from DLBCL, ultimately paving the way towards individualized therapeutic approaches.

This review consolidates the current molecular insights into aggressive and virus-associated B-NHL, taking into consideration the recently updated 5th edition of the WHO classification of hematolymphoid tumors (WHO-5HAEM) and the International Consensus Classification (ICC). Additionally, potential therapeutically targetable susceptibilities are highlighted, offering a comprehensive overview of the present scientific landscape in the field.

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最新进展:与病毒相关的高级别 B 细胞非霍奇金淋巴瘤的分子谱
侵袭性 B 细胞非霍奇金肿瘤(B-NHL)的种类繁多,包括几种与病毒感染相关的不常见实体,给从业人员的诊断带来了挑战。在新兴的精准肿瘤学时代,恶性肿瘤的分子特征描述具有极其重要的意义。对特定实体的病理生理学理解和靶向治疗方案的确定得到了快速发展。然而,由于其罕见性,并非所有实体都经过了详尽的分子特征描述。无论从采用的方法还是研究病例的规模来看,现有的研究工作都存在相当大的异质性。目前,治疗策略主要来自对弥漫大 B 细胞淋巴瘤(DLBCL)的观察,这是侵袭性 B-NHL 中最常见的亚群。本综述结合最近更新的第五版世界卫生组织血淋巴肿瘤分类(WHO-5HAEM)和国际共识分类(ICC),综述了目前对侵袭性和病毒相关 B-NHL 的分子研究。此外,还强调了潜在的治疗靶点易感性,全面概述了该领域目前的科学状况。
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来源期刊
Blood Reviews
Blood Reviews 医学-血液学
CiteScore
13.80
自引率
1.40%
发文量
78
期刊介绍: Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.
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