Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin

IF 7.9 2区 医学 Q1 IMMUNOLOGY Mucosal Immunology Pub Date : 2024-04-01 DOI:10.1016/j.mucimm.2024.01.003
Dylan Launder , John T. Dillon , Leah M. Wuescher , Trevor Glanz , Nora Abdul-Aziz , Elise Mein-Chiain Yi , Julian R. Naglik , Randall G. Worth , Heather R. Conti
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Abstract

The fungus Candida albicans can cause mucosal infections including oropharyngeal candidiasis (OPC) in immunocompromised patients. In humans, an increased risk of fungal infections correlates with thrombocytopenia. However, our understanding of platelets and megakaryocytes (Mks) in mucosal fungal infections is almost entirely unknown. When megakaryocyte- and platelet-depleted mice were infected with OPC, the tongue showed higher fungal burden, due to decreased neutrophil accumulation. Protection depended on a distinct population of oral-resident Mks. Interleukin-17, important in antifungal immunity, was required since mice lacking the IL-17 receptor had decreased circulating platelets and their oral Mks did not expand during OPC. The secretion of the peptide toxin candidalysin activated human Mks to release platelets with antifungal capacity. Infection with a candidalysin-deficient strain resulted in decreased expansion of tongue Mks during OPC. This is the first time that a distinct megakaryocyte population was identified in the oral mucosa which is critical for immunity against fungal infection.

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由 IL-17 和念珠菌素激活的口腔巨核细胞介导的致病性粘膜白僵菌感染免疫。
真菌白色念珠菌可引起粘膜感染,包括免疫力低下患者的口咽念珠菌病(OPC)。在人体中,真菌感染风险的增加与血小板减少有关。然而,我们对血小板和巨核细胞在粘膜真菌感染中的作用几乎一无所知。当巨核细胞和血小板缺失的小鼠感染 OPC 时,由于中性粒细胞聚集减少,舌头显示出更高的真菌负荷。保护作用取决于口腔巨核细胞的独特群体。白细胞介素-17在抗真菌免疫中非常重要,而缺乏白细胞介素-17受体的小鼠循环血小板减少,口腔巨核细胞在OPC期间也不会增大,因此需要白细胞介素-17。多肽毒素念珠菌素的分泌激活了人类巨核细胞,使其释放出具有抗真菌能力的血小板。感染念珠菌素缺陷菌株会导致舌巨核细胞在 OPC 期间扩张减少。这是首次在口腔粘膜中发现对真菌感染免疫至关重要的独特巨核细胞群。
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来源期刊
Mucosal Immunology
Mucosal Immunology 医学-免疫学
CiteScore
16.60
自引率
3.80%
发文量
100
审稿时长
12 days
期刊介绍: Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.
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