Cardiac effects of myoregulin in ischemia-reperfusion

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-01-19 DOI:10.1016/j.peptides.2024.171156

Sarah Appleby , Hamish M. Aitken-Buck , Mark S. Holdaway , Mathew S. Byers , Chris M. Frampton , Louise N. Paton , A. Mark Richards , Regis R. Lamberts , Christopher J. Pemberton

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Abstract

Myoregulin is a recently discovered micropeptide that controls calcium levels by inhibiting the intracellular calcium pump sarco-endoplasmic reticulum Ca²⁺-ATPase (SERCA). Keeping calcium levels balanced in the heart is essential for normal heart functioning, thus myoregulin has the potential to be a crucial regulator of cardiac muscle performance by reducing the rate of intracellular Ca²⁺ uptake. We provide the first report of myoregulin mRNA expression in human heart tissue, absence of expression in human plasma, and the effects of myoregulin on cardiac hemodynamics in an ex vivo Langendorff isolated rat heart model of ischemia/reperfusion. In this preliminary study, myoregulin provided a cardio-protective effect, as assessed by preservation of left ventricular contractility and relaxation, during ischemia/reperfusion. This study provides the foundation for future research in this area.

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肌球蛋白在缺血再灌注中对心脏的影响

肌球蛋白是最近发现的一种微肽，它通过抑制细胞内钙泵肉芽质内网Ca2+-ATP酶（SERCA）来控制钙水平。保持心脏中钙水平的平衡对心脏的正常功能至关重要，因此肌球蛋白有可能通过降低细胞内 Ca2+ 的摄取率成为心肌性能的重要调节因子。我们首次报道了肌球蛋白在人体心脏组织中的 mRNA 表达、在人体血浆中的缺失表达，以及肌球蛋白在缺血/再灌注的体外 Langendorff 离体大鼠心脏模型中对心脏血流动力学的影响。在这项初步研究中，肌球蛋白在缺血/再灌注过程中具有保护心脏的作用，具体表现为左心室收缩力和舒张力的保持。这项研究为今后该领域的研究奠定了基础。

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来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.