The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases.

IF 10.8 1区医学 Q1 NEUROSCIENCES Translational Neurodegeneration Pub Date : 2024-01-22 DOI:10.1186/s40035-024-00398-w

Arazu Sharif, John Mamo, Virginie Lam, Hani Al-Salami, Armin Mooranian, Gerald F Watts, Roger Clarnette, Giuseppe Luna, Ryu Takechi

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Abstract

Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blood-brain barrier (BBB) integrity. Addressing such multifaceted pathways necessitates the development of multi-target therapeutic strategies. Emerging research indicates that probucol, a historic lipid-lowering medication, offers substantial potential in the realm of neurodegenerative disease prevention and treatment. Preclinical investigations have unveiled multifaceted cellular effects of probucol, showcasing its remarkable antioxidative and anti-inflammatory properties, its ability to fortify the BBB and its direct influence on neural preservation and adaptability. These diverse effects collectively translate into enhancements in both motor and cognitive functions. This review provides a comprehensive overview of recent findings highlighting the efficacy of probucol and probucol-related compounds in the context of various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and cognitive impairment associated with diabetes.

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丙谷酚和丙谷酚类似物在神经退行性疾病中的治疗潜力。

神经退行性疾病的病理复杂，以各种相互关联的因素为特征，包括折叠错误的蛋白质聚集、氧化应激、神经炎症和血脑屏障（BBB）完整性受损。要解决这些多方面的途径，就必须开发多靶点治疗策略。新近的研究表明，普罗布考这种历史悠久的降脂药物在预防和治疗神经退行性疾病领域具有巨大的潜力。临床前研究揭示了丙谷醇对细胞的多方面影响，展示了其显著的抗氧化和抗炎特性、强化生物BB的能力以及对神经保护和适应性的直接影响。这些不同的效应共同作用于运动和认知功能的增强。这篇综述全面概述了最近的研究成果，重点介绍了益普糖醇和益普糖醇相关化合物在各种神经退行性疾病（包括阿尔茨海默病、帕金森病、亨廷顿氏病以及与糖尿病相关的认知障碍）中的功效。

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来源期刊

Translational Neurodegeneration Neuroscience-Cognitive Neuroscience

CiteScore

19.50

自引率

0.80%

发文量

审稿时长

10 weeks

期刊介绍： Translational Neurodegeneration, an open-access, peer-reviewed journal, addresses all aspects of neurodegenerative diseases. It serves as a prominent platform for research, therapeutics, and education, fostering discussions and insights across basic, translational, and clinical research domains. Covering Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions, it welcomes contributions on epidemiology, pathogenesis, diagnosis, prevention, drug development, rehabilitation, and drug delivery. Scientists, clinicians, and physician-scientists are encouraged to share their work in this specialized journal tailored to their fields.