Lumbar Disc Degeneration Is Linked to Dorsal Subcutaneous Fat Thickness at the L1-L2 Intervertebral Disc Level Measured by MRI.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-01-17 DOI:10.3390/tomography10010012

Ibrahem Hussain Kanbayti, Abdulrahman S Al-Buqami, Mohammad H Alsheikh, Saad M Al-Malki, Ibrahim Hadadi, Adnan Alahmadi, Bander S Almutairi, Hamzah H Ahmed

{"title":"Lumbar Disc Degeneration Is Linked to Dorsal Subcutaneous Fat Thickness at the L1-L2 Intervertebral Disc Level Measured by MRI.","authors":"Ibrahem Hussain Kanbayti, Abdulrahman S Al-Buqami, Mohammad H Alsheikh, Saad M Al-Malki, Ibrahim Hadadi, Adnan Alahmadi, Bander S Almutairi, Hamzah H Ahmed","doi":"10.3390/tomography10010012","DOIUrl":null,"url":null,"abstract":"Background: Obese individuals have a higher risk of degenerative disc disease (DDD). Currently, body mass index is not sensitive enough to differentiate between muscle and fat distribution, and obesity-related health issues are linked to the way body fat is distributed. Therefore, this study aims to investigate the association between the dorsal subcutaneous fat thickness (DSFT) of the lumbar spine, an alternative measurement tool of body fat distribution, and DDD.Methods: A total of 301 patients with DDD and 123 participants without the disease were recruited. Using length functions of magnetic resonance imaging (MRI) console, the DSFT of L1 to S1 intervertebral disc levels was measured in mid-sagittal spin-echo T2 weighted image. The Mann-Whitney U test and Chi-squared test (X2) were utilized to examine any variations between the case and control groups. Logistic regression models were built to explore the association of the DSFT with DDD.Results: The logistical regression model showed a positive association between DDD and DSFT [OR: 1.30, 95% CI: 1.02-1.64, p = 0.03]. In the stratified logistic regression analysis, a positive association was found between DDD and DSFT among younger participants and females [OR young: 1.48; 95% CI (1.02-2.20); p = 0.04-OR female: 1.37; 95% CI (1-1.88); p = 0.05].Conclusions: Younger females with thicker DSFT at the L1-L2 level are more likely to develop DDD. This suggests that increased DSFT may be a contributing factor to DDD.","PeriodicalId":51330,"journal":{"name":"Tomography","volume":"10 1","pages":"159-168"},"PeriodicalIF":2.2000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10820047/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tomography","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/tomography10010012","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Obese individuals have a higher risk of degenerative disc disease (DDD). Currently, body mass index is not sensitive enough to differentiate between muscle and fat distribution, and obesity-related health issues are linked to the way body fat is distributed. Therefore, this study aims to investigate the association between the dorsal subcutaneous fat thickness (DSFT) of the lumbar spine, an alternative measurement tool of body fat distribution, and DDD.

Methods: A total of 301 patients with DDD and 123 participants without the disease were recruited. Using length functions of magnetic resonance imaging (MRI) console, the DSFT of L1 to S1 intervertebral disc levels was measured in mid-sagittal spin-echo T2 weighted image. The Mann-Whitney U test and Chi-squared test (X2) were utilized to examine any variations between the case and control groups. Logistic regression models were built to explore the association of the DSFT with DDD.

Results: The logistical regression model showed a positive association between DDD and DSFT [OR: 1.30, 95% CI: 1.02-1.64, p = 0.03]. In the stratified logistic regression analysis, a positive association was found between DDD and DSFT among younger participants and females [OR _young: 1.48; 95% CI (1.02-2.20); p = 0.04-OR _female: 1.37; 95% CI (1-1.88); p = 0.05].

Conclusions: Younger females with thicker DSFT at the L1-L2 level are more likely to develop DDD. This suggests that increased DSFT may be a contributing factor to DDD.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

通过核磁共振成像测量腰椎间盘退变与 L1-L2 椎间盘水平的背侧皮下脂肪厚度有关。

背景：肥胖者患椎间盘退行性疾病（DDD）的风险较高。目前，体重指数还不足以灵敏地区分肌肉和脂肪的分布，而肥胖相关的健康问题与体内脂肪的分布方式有关。因此，本研究旨在调查腰椎背侧皮下脂肪厚度（DSFT）与腰椎间盘突出症之间的关联，DSFT是测量身体脂肪分布的另一种工具：方法：共招募了 301 名腰椎间盘突出症患者和 123 名非患者。使用磁共振成像（MRI）控制台的长度函数，在中矢状面自旋回波 T2 加权图像中测量 L1 至 S1 椎间盘水平的 DSFT。采用 Mann-Whitney U 检验和 Chi-squared 检验 (X2) 检验病例组和对照组之间的差异。建立了逻辑回归模型，以探讨 DSFT 与 DDD 的关联：逻辑回归模型显示，DDD 与 DSFT 呈正相关[OR：1.30，95% CI：1.02-1.64，p = 0.03]。在分层逻辑回归分析中，年轻参与者和女性的 DDD 与 DSFT 呈正相关[年轻 OR：1.48；95% CI (1.02-2.20)；p = 0.04-OR 女性：1.37；95% CI (1-1.88)；p = 0.05]：结论：L1-L2水平DSFT较厚的年轻女性更容易患DDD。结论：L1-L2水平DSFT较厚的年轻女性更容易罹患DDD，这表明DSFT的增加可能是导致DDD的一个因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.