Influence of cell volume on the gene transcription rate

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2024-01-19 DOI:10.1016/j.bbagrm.2024.195008

José E. Pérez-Ortín , María J. García-Marcelo , Irene Delgado-Román , María C. Muñoz-Centeno , Sebastián Chávez

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Abstract

Cells vary in volume throughout their life cycle and in many other circumstances, while their genome remains identical. Hence, the RNA production factory must adapt to changing needs, while maintaining the same production lines. This paradox is resolved by different mechanisms in distinct cells and circumstances. RNA polymerases have evolved to cope with the particular circumstances of each case and the different characteristics of the several RNA molecule types, especially their stabilities. Here we review current knowledge on these issues. We focus on the yeast Saccharomyces cerevisiae, where many of the studies have been performed, although we compare and discuss the results obtained in other eukaryotes and propose several ideas and questions to be tested and solved in the future.

Take away

−
The mRNA synthesis rate can be influenced by cell volume, and vice versa
−
Transcription and degradation rates must compensate reciprocally to maintain RNA homeostasis
−
Different cells and RNAs with diverse stabilities use distinct regulatory mechanisms
−
Asymmetrical division requires alternative transcription rate regulation with volume

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细胞体积对基因转录率的影响

细胞在整个生命周期和许多其他情况下，体积会发生变化，而基因组却保持不变。因此，RNA 生产工厂必须适应不断变化的需求，同时保持相同的生产线。这一矛盾在不同的细胞和环境中通过不同的机制得以解决。RNA 聚合酶不断进化，以应对每种情况下的特殊环境和几种 RNA 分子类型的不同特性，尤其是它们的稳定性。在此，我们回顾了目前有关这些问题的知识。我们将重点放在酵母菌上，因为许多研究都是在酵母菌上进行的，不过我们也会比较和讨论在其他真核生物中获得的结果，并提出一些想法和问题，供今后检验和解决。收获。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.