Variability in Neural Circuit Formation.

IF 6.9 2区 生物学 Q1 CELL BIOLOGY Cold Spring Harbor perspectives in biology Pub Date : 2024-03-01 DOI:10.1101/cshperspect.a041504
Kevin J Mitchell
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Abstract

The study of neural development is usually concerned with the question of how nervous systems get put together. Variation in these processes is usually of interest as a means of revealing these normative mechanisms. However, variation itself can be an object of study and is of interest from multiple angles. First, the nature of variation in both the processes and the outcomes of neural development is relevant to our understanding of how these processes and outcomes are encoded in the genome. Second, variation in the wiring of the brain in humans may underlie variation in all kinds of psychological and behavioral traits, as well as neurodevelopmental disorders. And third, genetic variation that affects circuit development provides the raw material for evolutionary change. Here, I examine these different aspects of variation in circuit development and consider what they may tell us about these larger questions.

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神经回路形成的变异性
神经发育研究通常关注的问题是神经系统是如何组合在一起的。这些过程中的变异通常是揭示这些规范机制的一种手段,因而备受关注。然而,变异本身也可以成为研究对象,并从多个角度引起人们的兴趣。首先,神经发育过程和结果的变异性质与我们对这些过程和结果如何在基因组中编码的理解有关。其次,人类大脑线路的变异可能是各种心理和行为特征以及神经发育疾病变异的基础。第三,影响电路发展的基因变异为进化变化提供了原材料。在这里,我将从这些不同的方面研究电路发育的变异,并思考它们可能会告诉我们这些更大的问题。
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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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