Symptomatic Intracranial Hemorrhage after Mechanical Thrombectomy - the Difference between Iso-Osmolar and Low-Osmolar Contrast Media.

Journal of neuroendovascular therapy Pub Date : 2023-01-01 Epub Date: 2023-12-08 DOI:10.5797/jnet.oa.2023-0074
Takeshi Wada, Katsutoshi Takayama, Kaoru Myouchin, Hayato Kishida, Yuto Chanoki, Keisuke Oshima, Takahiro Masutani, Yoshitomo Uchiyama, Toshihiro Tanaka
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Abstract

Objective: Symptomatic intracranial hemorrhage (SICH) after mechanical thrombectomy (MT) is generally considered a critical complication. Hemorrhagic transformation after ischemic stroke has also been associated with contrast media administration. The objective of our study was to evaluate correlations between contrast media type and incidence of SICH after MT.

Methods: Ninety-three consecutive patients (41 men; mean age, 80.2 years; range, 44-98 years) underwent MT reperfusion (expanded thrombolysis in cerebral infarction score, 2a-3) for acute large-vessel occlusion ischemic stroke within 8 h after symptom onset between April 2020 and July 2023 were retrospectively reviewed. Correlations between contrast media type (iso-osmolar or low-osmolar medium) and incidence of SICH were assessed.

Results: Contrast media were iso-osmolar in 60 cases or low-osmolar in 33 cases. The overall incidence of SICH was 5.5%. The frequency of SICH was significantly lower in the iso-osmolar group (1.7%) than in the low-osmolar group (12.1%; P = 0.033).

Conclusion: Iso-osmolar contrast media was associated with a lower incidence of SICH compared with low-osmolar contrast media in patients after MT.

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机械血栓切除术后的症状性颅内出血--等渗透压和低渗透压造影剂的区别。
目的:机械取栓术(MT)后的症状性颅内出血(SICH)通常被认为是一种严重的并发症。缺血性卒中后的出血转化也与造影剂的使用有关。我们的研究旨在评估造影剂类型与 MT 后 SICH 发生率之间的相关性:回顾性分析了 2020 年 4 月至 2023 年 7 月间因急性大血管闭塞性缺血性卒中在症状出现后 8 小时内接受 MT 再灌注(扩大脑梗塞溶栓评分 2a-3)的 93 例连续患者(41 例男性,平均年龄 80.2 岁,范围 44-98 岁)。评估了造影剂类型(等摩尔或低摩尔介质)与 SICH 发生率之间的相关性:结果:60 例造影剂为等渗透介质,33 例为低渗透介质。SICH 的总发生率为 5.5%。结论:等渗组的 SICH 发生率(1.7%)明显低于低渗组(12.1%;P = 0.033):结论:与低渗透压造影剂相比,等渗透压造影剂与 MT 患者较低的 SICH 发生率相关。
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