{"title":"Digging into the intrinsic capacity concept: Can it be applied to Alzheimer’s disease?","authors":"Susana López-Ortiz , Giuseppe Caruso , Enzo Emanuele , Héctor Menéndez , Saúl Peñín-Grandes , Claudia Savia Guerrera , Filippo Caraci , Robert Nisticò , Alejandro Lucia , Alejandro Santos-Lozano , Simone Lista","doi":"10.1016/j.pneurobio.2024.102574","DOIUrl":null,"url":null,"abstract":"<div><p>Historically, aging research has largely centered on disease pathology rather than promoting healthy aging. The World Health Organization’s (WHO) policy framework (2015–2030) underscores the significance of fostering the contributions of older individuals to their families, communities, and economies. The WHO has introduced the concept of intrinsic capacity (IC) as a key metric for healthy aging, encompassing five primary domains: locomotion, vitality, sensory, cognitive, and psychological. Past AD research, constrained by methodological limitations, has focused on single outcome measures, sidelining the complexity of the disease. Our current scientific milieu, however, is primed to adopt the IC concept. This is due to three critical considerations: (I) the decline in IC is linked to neurocognitive disorders, including AD, (II) cognition, a key component of IC, is deeply affected in AD, and (III) the cognitive decline associated with AD involves multiple factors and pathophysiological pathways. Our study explores the application of the IC concept to AD patients, offering a comprehensive model that could revolutionize the disease’s diagnosis and prognosis. There is a dearth of information on the biological characteristics of IC, which are a result of complex interactions within biological systems. Employing a systems biology approach, integrating omics technologies, could aid in unraveling these interactions and understanding IC from a holistic viewpoint. This comprehensive analysis of IC could be leveraged in clinical settings, equipping healthcare providers to assess AD patients’ health status more effectively and devise personalized therapeutic interventions in accordance with the precision medicine paradigm. We aimed to determine whether the IC concept could be extended from older individuals to patients with AD, thereby presenting a model that could significantly enhance the diagnosis and prognosis of this disease.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":null,"pages":null},"PeriodicalIF":6.7000,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301008224000108","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Historically, aging research has largely centered on disease pathology rather than promoting healthy aging. The World Health Organization’s (WHO) policy framework (2015–2030) underscores the significance of fostering the contributions of older individuals to their families, communities, and economies. The WHO has introduced the concept of intrinsic capacity (IC) as a key metric for healthy aging, encompassing five primary domains: locomotion, vitality, sensory, cognitive, and psychological. Past AD research, constrained by methodological limitations, has focused on single outcome measures, sidelining the complexity of the disease. Our current scientific milieu, however, is primed to adopt the IC concept. This is due to three critical considerations: (I) the decline in IC is linked to neurocognitive disorders, including AD, (II) cognition, a key component of IC, is deeply affected in AD, and (III) the cognitive decline associated with AD involves multiple factors and pathophysiological pathways. Our study explores the application of the IC concept to AD patients, offering a comprehensive model that could revolutionize the disease’s diagnosis and prognosis. There is a dearth of information on the biological characteristics of IC, which are a result of complex interactions within biological systems. Employing a systems biology approach, integrating omics technologies, could aid in unraveling these interactions and understanding IC from a holistic viewpoint. This comprehensive analysis of IC could be leveraged in clinical settings, equipping healthcare providers to assess AD patients’ health status more effectively and devise personalized therapeutic interventions in accordance with the precision medicine paradigm. We aimed to determine whether the IC concept could be extended from older individuals to patients with AD, thereby presenting a model that could significantly enhance the diagnosis and prognosis of this disease.
从历史上看,老龄化研究主要集中在疾病病理方面,而不是促进健康老龄化。世界卫生组织(WHO)的政策框架(2015-2030 年)强调了促进老年人为家庭、社区和经济做出贡献的重要性。世卫组织提出了内在能力(IC)的概念,将其作为衡量健康老龄化的关键指标,包括五个主要领域:运动、活力、感官、认知和心理。过去的注意力缺失症研究受方法论限制,只关注单一的结果测量,忽略了疾病的复杂性。然而,我们当前的科学环境已经为采用 IC 概念做好了准备。这主要是基于以下三点考虑:(I) 集成电路的衰退与神经认知障碍(包括注意力缺失症)有关;(II) 认知是集成电路的关键组成部分,在注意力缺失症中深受影响;(III) 与注意力缺失症相关的认知衰退涉及多种因素和病理生理途径。我们的研究探讨了 IC 概念在 AD 患者中的应用,提供了一个全面的模型,可以彻底改变该疾病的诊断和预后。IC是生物系统内部复杂相互作用的结果,目前有关IC生物学特征的信息还很匮乏。采用系统生物学的方法,并结合 Omics 技术,有助于揭示这些相互作用,并从整体角度理解 IC。这种对集成电路的全面分析可在临床环境中加以利用,使医疗服务提供者能够更有效地评估注意力缺失症患者的健康状况,并根据精准医疗范例制定个性化的治疗干预措施。我们的目的是确定能否将 IC 概念从老年人扩展到注意力缺失症患者,从而提出一种可显著提高该疾病诊断和预后的模型。
期刊介绍:
Progress in Neurobiology is an international journal that publishes groundbreaking original research, comprehensive review articles and opinion pieces written by leading researchers. The journal welcomes contributions from the broad field of neuroscience that apply neurophysiological, biochemical, pharmacological, molecular biological, anatomical, computational and behavioral analyses to problems of molecular, cellular, developmental, systems, and clinical neuroscience.