The Anti-Apoptotic Effect of Ranolazine on Cerebral Protection during Cardiopulmonary Bypass and Carotid Artery Surgery.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Acta Cardiologica Sinica Pub Date : 2024-01-01 DOI:10.6515/ACS.202401_40(1).20230814C

Engin Akgul, Meliha Koldemir Gunduz, Ali İhsan Parlar, Yesim Guner, Murat Eroglu, Abdulkerim Ozhan, Gulen Sezer Alptekin, Ahmet Cekirdekci

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Abstract

Background: We aimed to determine the usability of ranolazine (Rn) as a neuroprotective during cardiac surgeries and carotid artery interventions where cerebral blood flow is interrupted.

Methods: Female Wistar albino rats were used. The rats were divided into 4 groups of 8 rats each. The first group (Group 1) was the control group. Group 2 underwent ischemia induction but was not treated with Rn. Group 3 received 25 mg/kg/day and Group 4 50 mg/kg/day Rn intraperitoneally, starting 3 days before ischemia induction. Bilateral carotid arteries were explored and clamped simultaneously. Ischemia was induced for 15 minutes. After 72 hours, the experimental animals were sacrificed.

Results: Superoxide dismutase, alkaline phosphatase, and interleukin 6 levels were similar among the 4 groups. Acetylcholine esterase (Group 3: p = 0.007, Group 4: p = 0.002), tumor necrosis factor-alpha (Group 4: p = 0.01), and annexin V (Group 3: p = 0.001) levels were statistically significantly lower in the Rn-treated groups. Malondialdehyde (Group 3: p = 0.003, Group 4: p = 0.009), reduced glutathione (Group 4: p = 0.04), acid phosphatase (Group 3: p = 0.04), noradrenaline (Group 3: p = 0.01), and Bcl-2 (Group 4: p = 0.004) levels were significantly higher in the Rn-treated groups.

Conclusions: The results of this study demonstrated the antiapoptotic effect of Rn in a brain ischemia-reperfusion model of rats receiving Rn before the procedure.

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雷诺嗪对心肺旁路和颈动脉手术中大脑保护的抗凋亡作用

背景：我们的目的是确定雷诺拉嗪（Rn）作为神经保护剂在心脏手术和颈动脉介入手术中脑血流中断时的可用性：方法：使用雌性 Wistar 白化大鼠。方法：使用雌性 Wistar 白化大鼠，将其分为 4 组，每组 8 只。第一组（第 1 组）为对照组。第 2 组接受缺血诱导，但未接受 Rn 治疗。第 3 组在缺血诱导前 3 天开始腹腔注射 Rn，剂量为 25 毫克/千克/天，第 4 组为 50 毫克/千克/天。同时探查并钳夹双侧颈动脉。诱导缺血 15 分钟。72 小时后，实验动物被处死：结果：4 组动物的超氧化物歧化酶、碱性磷酸酶和白细胞介素 6 水平相似。乙酰胆碱酯酶（第 3 组：p = 0.007，第 4 组：p = 0.002）、肿瘤坏死因子-α（第 4 组：p = 0.01）和附子素 V（第 3 组：p = 0.001）水平在 Rn 处理组明显降低。丙二醛（第 3 组：p = 0.003，第 4 组：p = 0.009）、还原型谷胱甘肽（第 4 组：p = 0.04）、酸性磷酸酶（第 3 组：p = 0.04）、去甲肾上腺素（第 3 组：p = 0.01）和 Bcl-2（第 4 组：p = 0.004）水平在 Rn 治疗组明显升高：本研究结果表明，在脑缺血再灌注模型中，术前接受 Rn 治疗的大鼠具有抗凋亡作用。

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来源期刊

Acta Cardiologica Sinica 医学-心血管系统

CiteScore

2.90

自引率

15.80%

发文量

144

审稿时长

>12 weeks

期刊介绍： Acta Cardiologica Sinica welcomes all the papers in the fields related to cardiovascular medicine including basic research, vascular biology, clinical pharmacology, clinical trial, critical care medicine, coronary artery disease, interventional cardiology, arrythmia and electrophysiology, atherosclerosis, hypertension, cardiomyopathy and heart failure, valvular and structure cardiac disease, pediatric cardiology, cardiovascular surgery, and so on. We received papers from more than 20 countries and areas of the world. Currently, 40% of the papers were submitted to Acta Cardiologica Sinica from Taiwan, 20% from China, and 20% from the other countries and areas in the world. The acceptance rate for publication was around 50% in general.