SOWAHB polymorphisms affect thyroid cancer risk in the Chinese Han population.

IF 3.9 3区医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-04-01 Epub Date: 2024-01-23 DOI:10.1080/14737159.2024.2305183

Man Zhang, Jing Liang, Junhui Han, Wenjing Zhang, Panpan Wan, Leteng Yang, Xufeng Zang, Wanli Ren, Ling Zhang, Hao Dai, Yue Wu, Tianbo Jin

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Abstract

Objectives: This study aimed to detect the correlation between SOWAHB polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.

Methods: We genotyped SOWAHB variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between SOWAHB polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.

Results: Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: p = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: p = 0.000, log-additive: p = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: p = 0.011, recessive: p = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: p = 0.030, dominant: p = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: p = 0.018, recessive: p = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: p = 0.001, dominant: p = 0.003).

Conclusion: SOWAHB SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.

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SOWAHB多态性影响中国汉族人群患甲状腺癌的风险。

研究目的本研究旨在检测中国汉族人群中SOWAHB多态性与甲状腺癌（TC）风险之间的相关性：方法：我们使用Agena MassARRAY对510名TC患者和509名对照者的SOWAHB变异进行了基因分型。我们评估了 SOWAHB 多态性与 TC 易感性之间的关联，并通过 FPRP 分析评估了显著结果。我们通过MDR分析SNP-SNP相互作用来预测TC风险：结果：rs2703129 CC携带者患TC的概率较低（显性、隐性：p = 0.002），而rs1874564 AG携带者患TC的风险较高（显性、隐性：p = 0.000，对数加成：p = 0.028）。在年龄大于 45 岁的受试者中，rs2703129 可降低 TC 易感性（显性：p = 0.011，隐性：p = 0.007），但 rs1874564 与 TC 风险之间的关联性增加（显性：p = 0.030，显性：p = 0.047）。此外，rs2703129 与男性 TC 风险较低有关（显性：p = 0.018，隐性：p = 0.013）。相反，rs1874564 与女性 TC 风险增加有关（共显性：p = 0.001，显性：p = 0.003）：结论：SOWAHB SNPs与TC的发生有关，rs2703129可能是TC的保护位点。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.