Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia.

IF 1.4 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International journal of occupational medicine and environmental health Pub Date : 2024-03-05 Epub Date: 2024-01-23 DOI:10.13075/ijomeh.1896.02292

Elizabeth Londoño-Velasco, Helberg Asencio-Santofimio, Jose Guillermo Ortega-Avila, Aldair Beryery Rosero-Caldón, Juan Carlos Aristizabal-Grisales, Laura Rey-Henao, Jairo Andres Vargas-Rivera, Enrique Vergara-Escudero

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Abstract

Objectives: This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia.

Material and methods: Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage.

Results: The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance.

Conclusions: The results between groups could be related to healthy habits and PPE use among the subjects. Int J Occup Med Environ Health. 2024;37(1):128-37.

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哥伦比亚卡利市接触杀虫剂的城市熏蒸工人口腔黏膜基因毒性评估。

研究目的本研究旨在评估哥伦比亚卡利市区未接触过杀虫剂的受试者（33 人）和接触过杀虫剂的熏蒸者（31 人）口腔黏膜的细胞遗传损伤：通过问卷调查收集社会人口学数据、人体测量数据、健康状况和生活方式。采用口腔微核细胞组（BMCyt）检测法评估细胞遗传损伤：研究表明，所有熏蒸者都使用了适当的个人防护设备（PPE），且饮酒量较低。作者未发现各组之间的 BMCyt 生物标志物存在明显差异（P > 0.05）。多变量分析显示，年龄每增加一岁，微核（MN）频率增加 13%（OR = 1.13，p = 0.029），每日水果摄入量减少，MN 增加（OR = 4.71，p = 0.084），但无统计学意义：各组之间的结果可能与受试者的健康习惯和个人防护设备的使用有关。Int J Occup Med Environ Health.2024;37(1).

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来源期刊

International journal of occupational medicine and environmental health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.40

自引率

5.00%

发文量

审稿时长

7.5 months

期刊介绍： The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.