Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study.

IF 6.9 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Journal of Gastroenterology Pub Date : 2024-03-01 Epub Date: 2024-01-23 DOI:10.1007/s00535-023-02074-8

Kazuhito Sasaki, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Hideyuki Ishida, Keiichiro Ishibashi, Yoshiko Mori, Satoki Shichijo, Yasuhiro Tani, Yoji Takeuchi, Akiko Chino, Misato Takao, Kenji Fujiyoshi, Takaaki Matsubara, Yasuyuki Miyakura, Fumitaka Taniguchi, Tatsuro Yamaguchi, Kohji Tanakaya, Naohiro Tomita, Yoichi Ajioka

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Abstract

Background: Patients with familial adenomatous polyposis (FAP) have an increased risk of developing gastric neoplasms. However, the clinical course of FAP with these gastric lesions has not yet been fully clarified. The present study aimed to clarify the changes in the incidence risk of developing gastric adenoma or gastric cancer during the lifespan of patients with FAP.

Methods: Four hundred forty-three patients with data regarding gastric adenoma and gastric cancer retrospectively registered in a nationwide Japanese multicenter study were enrolled. The cumulative incidences and hazard rates (HRs) of gastric neoplasms were evaluated.

Results: The cumulative incidence rates in 50-year-old patients with FAP were 22.8% for gastric adenoma and 7.6% for gastric cancer, respectively. No significant association was found between gastric neoplasms and the colonic phenotype. The peak age for the HR of gastric adenoma was 65 years, with the highest HR (0.043). Regarding the incidence of gastric cancer, the HR increased moderately up to the age of 40 years, but the increase accelerated from the age of 50 years (HR = 0.0067).

Conclusion: Careful surveillance of the upper gastrointestinal tract in elderly patients with FAP, such as shortening the interval of follow-up according to age, may be helpful for early diagnosis of gastric cancer.

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日本家族性腺瘤性息肉病患者罹患胃腺瘤和腺癌的风险：一项全国性多中心研究。

背景：家族性腺瘤性息肉病（FAP）患者罹患胃肿瘤的风险较高。然而，家族性腺瘤性息肉病（FAP）患者胃部病变的临床过程尚未完全明确。本研究旨在阐明 FAP 患者在其生命周期中发生胃腺瘤或胃癌的发病风险变化：方法：本研究纳入了在日本全国多中心研究中回顾性登记的 443 例有胃腺瘤和胃癌相关数据的患者。评估了胃肿瘤的累积发病率和危险率（HRs）：结果：在 50 岁的 FAP 患者中，胃腺瘤和胃癌的累积发病率分别为 22.8%和 7.6%。胃肿瘤与结肠表型之间无明显关联。胃腺瘤 HR 的高峰年龄为 65 岁，HR 最高（0.043）。关于胃癌的发病率，40岁以下的HR略有上升，但从50岁开始上升速度加快（HR = 0.0067）：结论：对老年 FAP 患者的上消化道进行仔细监测，如根据年龄缩短随访间隔，可能有助于早期诊断胃癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

12.20

自引率

1.60%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal of Gastroenterology, which is the official publication of the Japanese Society of Gastroenterology, publishes Original Articles (Alimentary Tract/Liver, Pancreas, and Biliary Tract), Review Articles, Letters to the Editors and other articles on all aspects of the field of gastroenterology. Significant contributions relating to basic research, theory, and practice are welcomed. These publications are designed to disseminate knowledge in this field to a worldwide audience, and accordingly, its editorial board has an international membership.