Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort

IF 5.3 2区医学 Q1 PSYCHIATRY Acta Psychiatrica Scandinavica Pub Date : 2024-01-24 DOI:10.1111/acps.13655

O. Godin, E. Olié, G. Fond, B. Aouizerate, V. Aubin, F. Bellivier, R. Belzeaux, P. Courtet, C. Dubertret, E. Haffen, A. Lefrere, P. M. Llorca, M. Polosan, P. Roux, L. Samalin, R. Schwan, the FondaMental Academic Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators, M. Leboyer, B. Etain

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Abstract

Introduction

Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.

Methods

Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort and followed-up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow-up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow-up. We applied inverse probability-of-censoring weighting method to minimize selection bias due to loss during follow-up.

Results

Among individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow-up. Multivariable analyses showed that incident MetS during follow-up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7–3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40–3.25, p = 0.0004), presence of a mood recurrence during follow-up (OR = 1.91, 95% CI = 1.22–3.00, p = 0.0049), prolonged exposure to second-generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00–1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98–1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00–1.08), independently of the associations observed for baseline MetS components.

Conclusion

We observed a high incidence of MetS during a 3 years follow-up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.

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双相情感障碍患者代谢综合征的发病率和预测因素：FACE-BD队列纵向研究。

简介代谢综合征（MetS）是包括腹部肥胖、高血糖、高血压和血脂异常在内的一组疾病。代谢综合征在双相情感障碍（BD）患者中发病率很高，估计全球发病率为 32.6%。有关双相情感障碍患者MetS发病情况的纵向数据很少，而且样本量较小。本研究的目的是估计1521名躁狂症患者组成的大型纵向队列中MetS的发病率，并确定MetS发病的临床和生物学预测因素：方法：从方达精神科双相情感障碍高级专家中心（FACE-BD）队列中招募参与者，并对其进行为期3年的随访。MetS是根据国际糖尿病联盟的标准定义的。基线时没有 MetS，但在随访期间出现 MetS 的人被视为出现 MetS。我们采用逻辑回归模型来估算各因素与随访期间发生的 MetS 之间的调整后几率及其相应的 95% 置信区间 (CI)。我们采用了反删减概率加权法，以最大限度地减少随访过程中因失访造成的选择偏差：在基线时没有 MetS 的人群（n = 1521）中，19.3% 在随访期间患上 MetS。多变量分析显示，随访期间发生的 MetS 与男性性别显著相关（OR = 2.2，95% CI = 1.7-3.0，P 结论：我们观察到 MetS 的发生率很高：我们观察到，在 3 年的随访中，BD 患者的 MetS 发生率很高（19.3%）。找出预测因素有助于制定早期干预措施，预防或治疗早期 MetS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.