Compensation in neuro-system related to age-related hearing loss.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-01-24 DOI:10.1080/00016489.2023.2295400

Tongxiang Diao, Xin Ma, Xuan Fang, Maoli Duan, Lisheng Yu

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Abstract

Background: Age-related hearing loss (ARHL) is a major cause of chronic disability among the elderly. Individuals with ARHL not only have trouble hearing sounds, but also with speech perception. As the perception of auditory information is reliant on integration between widespread brain networks to interpret auditory stimuli, both auditory and extra-auditory systems which mainly include visual, motor and attention systems, play an important role in compensating for ARHL.

Objectives: To better understand the compensatory mechanism of ARHL and inspire better interventions that may alleviate ARHL.

Methods: We mainly focus on the existing information on ARHL-related central compensation. The compensatory effects of hearing aids (HAs) and cochlear implants (CIs) on ARHL were also discussed.

Results: Studies have shown that ARHL can induce cochlear hair cell damage or loss and cochlear synaptopathy, which could induce central compensation including compensation of auditory and extra-auditory neural networks. The use of HAs and CIs can improve bottom-up processing by enabling 'better' input to the auditory pathways and then to the cortex by enhancing the diminished auditory signal.

Conclusions: The central compensation of ARHL and its possible correlation with HAs and CIs are current hotspots in the field and should be given focus in future research.

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与老年性听力损失有关的神经系统补偿。

背景：老年性听力损失（ARHL）是导致老年人长期残疾的一个主要原因。患有老年性听力损失的人不仅听力有问题，而且言语感知也有问题。由于对听觉信息的感知依赖于广泛的大脑网络之间的整合来解释听觉刺激，因此听觉系统和听觉外系统（主要包括视觉、运动和注意力系统）在补偿 ARHL 方面发挥着重要作用：目的：更好地理解ARHL的代偿机制，启发更好的干预措施，以缓解ARHL：我们主要关注与 ARHL 相关的中枢补偿的现有信息。方法：我们主要关注与 ARHL 相关的中枢代偿的现有信息，同时还讨论了助听器（HA）和人工耳蜗（CI）对 ARHL 的代偿作用：研究表明，ARHL 可诱发耳蜗毛细胞损伤或缺失以及耳蜗突触病，从而诱发中枢代偿，包括听觉和听觉外神经网络的代偿。使用人工耳蜗和人工耳蜗可以改善自下而上的处理过程，使听觉通路获得 "更好 "的输入，然后通过增强减弱的听觉信号进入大脑皮层：ARHL的中枢补偿及其可能与HA和CIs的相关性是目前该领域的研究热点，也是未来研究的重点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.