Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Current Neurology and Neuroscience Reports Pub Date : 2024-03-01 Epub Date: 2024-01-25 DOI:10.1007/s11910-024-01331-4

Chi-Ying R Lin, Sheng-Han Kuo, Puneet Opal

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Abstract

Purpose of review: Spinocerebellar ataxias (SCAs) are autosomal dominant degenerative syndromes that present with ataxia and brain stem abnormalities. This review describes the cognitive and behavioral symptoms of SCAs in the context of recent knowledge of the role of the cerebellum in higher intellectual function.

Recent findings: Recent studies suggest that patients with spinocerebellar ataxia can display cognitive deficits even early in the disease. These have been given the term cerebellar cognitive affective syndrome (CCAS). CCAS can be tracked using newly developed rating scales. In addition, patients with spinocerebellar ataxia also display impulsive and compulsive behavior, depression, anxiety, fatigue, and sleep disturbances. This review stresses the importance of recognizing non-motor symptoms in SCAs. There is a pressing need for novel therapeutic interventions to address these symptoms given their deleterious impact on patients' quality of life.

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脊髓小脑性共济失调的认知、情感和其他非运动症状。

综述的目的：脊髓小脑共济失调症（SCA）是一种常染色体显性变性综合征，表现为共济失调和脑干异常。本综述结合小脑在高级智力功能中的作用这一最新知识，描述了脊髓小脑性共济失调症的认知和行为症状：最近的研究表明，脊髓小脑共济失调症患者甚至在患病早期就会出现认知障碍。这些症状被称为小脑认知情感综合征（CCAS）。CCAS可通过新开发的评分量表进行追踪。此外，脊髓小脑共济失调症患者还表现出冲动和强迫行为、抑郁、焦虑、疲劳和睡眠障碍。本综述强调了认识脊髓小脑共济失调症非运动症状的重要性。鉴于这些症状对患者生活质量的有害影响，迫切需要新型治疗干预措施来解决这些症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.