Pesticide use patterns and their association with cytokine levels in Mexican flower workers.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International Archives of Occupational and Environmental Health Pub Date : 2024-04-01 Epub Date: 2024-01-25 DOI:10.1007/s00420-023-02043-x

Brenda Mélany Godínez-Pérez, Astrid Schilmann, Alfredo Lagunas-Martínez, Consuelo Escamilla-Núñez, Ana Isabel Burguete-García, Clemente Aguilar-Garduño, Julia Blanco-Muñoz, Marina Lacasaña

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Abstract

Objective: Occupational exposure to pesticides is a known risk for disrupting cellular immune response in flower workers due to their use of multiple chemical products, poor work conditions, and inadequate protection. Recently, the analysis of pesticide use patterns has emerged as an alternative to studying exposure to mixtures of these products. This study aimed to evaluate the association between exposure to different patterns of pesticide use and the cytokine profile of flower workers in the State of Mexico and Morelos, Mexico.

Methods: A cross-sectional study was carried out on a population of 108 flower workers. Serum levels of IL-4, IL-5, IL-6, IL-8, IL-10 cytokines were analyzed by means of multiplex analysis, and TNF-α and IFN-γ using an ELISA test. Pesticide use patterns were generated by principal components analysis.

Results: The analysis revealed that certain patterns of pesticide use, combining insecticides and fungicides, were associated with higher levels of pro-inflammatory cytokines, particularly IL-6 and IFN-γ.

Conclusion: These findings indicate that pesticides may possess immunotoxic properties, contributing to increased inflammatory response. However, further comprehensive epidemiological studies are needed to establish a causal relationship.

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墨西哥花卉工人的杀虫剂使用模式及其与细胞因子水平的关系。

目的：由于花卉工人使用多种化学产品、工作条件差和防护措施不足，职业性接触杀虫剂已成为扰乱花卉工人细胞免疫反应的一个已知风险。最近，对杀虫剂使用模式的分析已成为研究接触这些产品混合物的一种替代方法。本研究旨在评估墨西哥墨西哥州和莫雷洛斯州花卉工人暴露于不同杀虫剂使用模式与细胞因子谱之间的关系：对 108 名花卉工人进行了横断面研究。采用多重分析法对血清中 IL-4、IL-5、IL-6、IL-8 和 IL-10 细胞因子的水平进行了分析，并采用 ELISA 测试法对 TNF-α 和 IFN-γ 的水平进行了分析。农药使用模式通过主成分分析得出：分析结果表明，杀虫剂和杀真菌剂相结合的某些杀虫剂使用模式与较高水平的促炎细胞因子有关，特别是 IL-6 和 IFN-γ：这些研究结果表明，杀虫剂可能具有免疫毒性，会导致炎症反应加剧。结论：这些研究结果表明，农药可能具有免疫毒性，会导致炎症反应增加，但要确定其中的因果关系，还需要进一步开展全面的流行病学研究。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.